exRNAdisease

Entry Detail

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General Information

Database ID: exR0365273 RNA Name: LDHA RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 18394560 End Site(bp): 18408425 External Links: ENSG00000134333

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AL136454.1 chr1 192716132 192716653 + AKIRIN1 chr1 38991276 39006059 + AJUBA chr14 22971177 22982551 - ADAR chr1 154582057 154628013 - AC073508.2 chr17 40627356 40665141 - AKAP11 chr13 42272152 42323261 + AKR1A1 chr1 45550543 45570049 + ABHD8 chr19 17292131 17310236 - AGTRAP chr1 11736084 11754802 + AC006030.1 chr2 74211604 74363377 - ADGRA3 chr4 22345071 22516066 - ACTR2 chr2 65227753 65271253 + AL022238.4 chr22 40346529 40410054 + ACTR1B chr2 97655939 97664044 - ACTR3 chr2 113890063 113962596 + ADCY1 chr7 45574140 45723116 + AL139353.1 chr14 31334312 31457441 - ACY3 chr11 67642555 67650730 - AC004922.1 chr7 99325879 99394653 + ACTG1 chr17 81509971 81523847 - ABCB7 chrX 75051048 75156732 - AL021546.1 chr12 120438198 120460006 + AL136295.5 chr14 24147548 24166452 + AAR2 chr20 36236459 36270918 + AC138811.2 chr16 18788063 18801519 - AC023055.1 chr12 55757275 55827546 - AIP chr11 67483026 67491103 + AC139530.2 chr17 81703371 81720539 + ABT1 chr6 26596953 26600739 + ADTRP chr6 11712054 11807046 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-302a-3p chr4 112648186 112648208 - hsa-miR-4426 chr1 192716333 192716349 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008870.2 chr16 23670011 23675499 + AC010442.1 chr5 466124 473098 - AC010655.2 chr7 128455937 128469197 + AC010655.4 chr7 128455840 128493859 + AC012236.1 chr15 31221999 31230838 - AC016876.2 chr17 7581964 7584086 - AC020663.1 chr16 4730115 4752565 - AC022098.1 chr19 14137146 14171267 + AC023509.1 chr12 53441741 53467528 + AC026362.1 chr12 122975320 122982907 + AC091564.7 chr11 6610883 6616594 - AC092368.3 chr16 46622861 46624451 - AC109460.3 chr16 28974804 28990775 + AL035458.2 chr20 34234840 34281173 - AL117378.1 chr6 131901963 131920565 + AL132780.1 chr14 22929607 22956374 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.