exRNAdisease

Entry Detail

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General Information

Database ID: exR0365764 RNA Name: MAZ RNA Type: mRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 29806106 End Site(bp): 29811164 External Links: ENSG00000103495

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AATF chr17 36948954 37056871 + AC008982.1 chr19 38817471 38840178 - AC010422.3 chr19 12643831 12648397 - AC010522.1 chr19 57819719 57858941 + AC114490.3 chr1 34974356 34985313 - AC124312.1 chr15 24955034 25000276 + AC131160.1 chr3 183815568 183884889 - AC245033.1 chr15 82536788 82573194 - ACAD9 chr3 128879596 128916067 + ACOX1 chr17 75941507 75979177 - ACTG1 chr17 81509971 81523847 - ACTR1B chr2 97655939 97664044 - ACVR1 chr2 157736444 157876330 - ADGRA3 chr4 22345071 22516066 - ADIPOR1 chr1 202940826 202958572 - AFDN chr6 167826922 167972023 + AGAP3 chr7 151085831 151144436 + AGBL5 chr2 27042364 27070622 + AGPAT3 chr21 43865223 43987592 + AHDC1 chr1 27534035 27604431 - AK2 chr1 33007940 33080996 - AKAP11 chr13 42272152 42323261 + AL121753.1 chr20 35267885 35280043 - AL139011.2 chr1 160216800 160285130 - AL162417.1 chr9 133098121 133163914 - AL928654.3 chr14 105487199 105492267 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-29a-3p chr7 130876748 130876769 - hsa-miR-92a-3p chrX 134169544 134169565 - hsa-miR-1181 chr19 10403505 10403525 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC009133.1 chr16 29808636 29821252 - AC009133.5 chr16 29808679 29812227 + AC011445.1 chr19 39314651 39320858 - AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC026464.2 chr16 69463844 69466264 + AC132217.1 chr11 2129121 2129964 - AC245014.3 chr1 145281116 145281462 + AC245033.4 chr15 82533175 82540008 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.