exRNAdisease

Entry Detail

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General Information

Database ID: exR0365811 RNA Name: MCM7 RNA Type: mRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 100092728 End Site(bp): 100101940 External Links: ENSG00000166508

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAR2 chr20 36236459 36270918 + AC010422.5 chr19 12664828 12669397 - AC037459.1 chr8 22589274 22602084 + AC073508.2 chr17 40627356 40665141 - AC091551.1 chr18 50968019 51058144 + AC131160.1 chr3 183815568 183884889 - AC245033.1 chr15 82536788 82573194 - ACADS chr12 120725774 120740008 + ACIN1 chr14 23058564 23095614 - ACTN3 chr11 66546395 66563334 + ACVR1B chr12 51951699 51997078 + ADAMTS1 chr21 26835755 26845409 - ADD2 chr2 70607618 70768225 - ADGRV1 chr5 90529344 91164437 + ADPGK chr15 72751369 72785846 - AGO2 chr8 140520156 140635633 - AHCY chr20 34280268 34311802 - AIF1L chr9 131096476 131123152 + AKT2 chr19 40230317 40285536 - AL513165.2 chr9 37512547 37592469 - ALDH18A1 chr10 95605941 95656711 - ALDH9A1 chr1 165662216 165698863 - ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-93-5p chr7 100093815 100093837 - hsa-miR-25-5p chr7 100093610 100093630 - hsa-miR-6790-3p chr19 6392925 6392945 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC016876.2 chr17 7581964 7584086 - AC091493.1 chr3 16687986 16697479 - AC091564.7 chr11 6610883 6616594 - AC106864.1 chr4 112693047 112706810 - AC132217.1 chr11 2129121 2129964 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.