exRNAdisease

Entry Detail

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General Information

Database ID: exR0365972 RNA Name: MIF RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 23894383 End Site(bp): 23895227 External Links: ENSG00000240972

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AIF1L chr9 131096476 131123152 + AC120057.2 chr17 7240427 7244635 - AL139300.1 chr14 103562962 103685924 + AHNAK chr11 62433542 62556235 - AIMP2 chr7 6009255 6023834 + AC024592.3 chr19 5866171 5903787 - AL121594.1 chr14 35122549 35317474 + ACTR1B chr2 97655939 97664044 - ALDH1L1 chr3 126103562 126197994 - ABCF1 chr6 30571393 30597179 + AC007192.1 chr19 18153158 18178117 + ABRACL chr6 139028745 139043302 + AHCY chr20 34280268 34311802 - AL645941.2 chr6 32937364 32953122 - ALDH3A2 chr17 19648136 19685760 + ACAP3 chr1 1292390 1309609 - AC091167.2 chr15 90249556 90272208 + AC010422.3 chr19 12643831 12648397 - ABCD3 chr1 94418389 94518666 + AC131160.1 chr3 183815568 183884889 - AC010132.3 chr7 42909273 42932174 - AL365205.1 chr6 41780349 41790141 + ACTB chr7 5527148 5563784 - ALDH9A1 chr1 165662216 165698863 - AC040162.1 chr16 67929614 67936017 - AAAS chr12 53307456 53324864 - AIDA chr1 222668013 222713210 - AKR7A2 chr1 19303965 19312146 - ACTR2 chr2 65227753 65271253 + ACAP1 chr17 7336529 7351477 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-320a-3p chr8 22244975 22244996 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004241.1 chr12 47706083 47742294 + AC016876.2 chr17 7581964 7584086 - AC023790.2 chr12 13000451 13040679 + AC026362.1 chr12 122975320 122982907 + AC051619.7 chr15 45200325 45200632 - AC108134.2 chr16 3156736 3157483 - AC245014.3 chr1 145281116 145281462 + AL022311.1 chr22 37876148 37895563 + AL121992.1 chr1 15586136 15603626 - AL137782.1 chr13 75549773 75807120 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.