exRNAdisease

Entry Detail

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General Information

Database ID: exR0366290 RNA Name: MTRNR2L8 RNA Type: mRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 10507894 End Site(bp): 10509186 External Links: ENSG00000255823

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049629.2 chr11 33698261 33722467 - AKR1B1 chr7 134442356 134459284 - ABCF2 chr7 151207837 151227166 - AL035078.4 chr11 31812391 32104665 + ADD1 chr4 2843857 2930076 + AGPAT5 chr8 6708642 6761503 + AGO3 chr1 35930718 36072500 + ADGRL2 chr1 81306160 81992436 + AC118549.1 chr1 77562416 77683419 - AC010463.1 chr19 17267418 17282966 + AC006064.6 chr12 6556886 6607367 - AJUBA chr14 22971177 22982551 - AC015813.2 chr17 57989038 58007246 - ACOT13 chr6 24667035 24705065 + ACACA chr17 37084992 37406836 - ADK chr10 74151202 74709963 + AGO1 chr1 35869808 35930532 + ADM2 chr22 50481543 50486440 + ACER3 chr11 76860867 77026797 + AFF1 chr4 86935002 87141054 + ADH5 chr4 99070978 99088801 - AHCY chr20 34280268 34311802 - ACSS1 chr20 25006230 25058980 - ACP1 chr2 264140 278283 + AC048338.1 chr12 122207779 122266423 - AL589666.1 chr6 85557978 85615234 - ABHD10 chr3 111979010 111993368 + ADGRG6 chr6 142301854 142446266 + ALDOA chr16 30064164 30070457 + ACAT1 chr11 108116695 108147603 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4485-3p chr11 10508277 10508296 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AC037198.1 chr15 39586561 39587293 + AC079600.3 chr12 42485353 42498979 - AC079781.5 chr7 97851688 97972985 - AC090204.1 chr8 32927913 33045445 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL135925.1 chr10 79825902 79827602 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.