exRNAdisease

Entry Detail

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General Information

Database ID: exR0367013 RNA Name: OAZ1 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 2269509 End Site(bp): 2273490 External Links: ENSG00000104904

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAGAB chr15 67200667 67255195 - ABCB8 chr7 151028422 151047782 + ABL2 chr1 179099330 179229684 - AC005258.1 chr19 2269525 2341172 + AC006030.1 chr2 74211604 74363377 - AC008982.1 chr19 38817471 38840178 - AC010422.3 chr19 12643831 12648397 - AC011455.2 chr19 38915404 38949855 - AC073508.2 chr17 40627356 40665141 - AC104109.3 chr5 134167170 134226071 - AC124312.1 chr15 24955034 25000276 + ACAT2 chr6 159762045 159779112 + ACLY chr17 41866917 41930542 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTL6A chr3 179562886 179588407 + ACTN1 chr14 68874143 68979440 - ACTR8 chr3 53867066 53882152 - ADAR chr1 154582057 154628013 - AEN chr15 88621337 88632281 + AHCTF1 chr1 246839098 246931967 - AHSA1 chr14 77457870 77469472 + AIFM1 chrX 130129362 130165887 - AKAP1 chr17 57085092 57121346 + AL133352.1 chr10 100505628 100529881 - AL139260.3 chr1 38864501 38881617 - ALCAM chr3 105366909 105576900 + ALDOA chr16 30064164 30070457 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC009908.1 chr8 124996985 124998198 - AC067930.1 chr8 143579636 143580670 + AC079145.1 chr2 19990209 20004795 + AC087392.5 chr17 795306 795794 + AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.