exRNAdisease

Entry Detail

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General Information

Database ID: exR0367248 RNA Name: P4HB RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 81843161 End Site(bp): 81860624 External Links: ENSG00000185624

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCB7 chrX 75051048 75156732 - ABCF2 chr7 151207837 151227166 - ABLIM1 chr10 114431113 114768061 - ABR chr17 1003518 1229738 - AC010132.3 chr7 42909273 42932174 - AC015813.2 chr17 57989038 58007246 - AC087289.3 chr17 75898645 75930129 - ACAD11 chr3 132558138 132660082 - ACLY chr17 41866917 41930542 - ACOT9 chrX 23701055 23766475 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTR3 chr2 113890063 113962596 + ADD2 chr2 70607618 70768225 - ADORA2A chr22 24417879 24442357 + ADPRHL2 chr1 36088892 36093932 + ADSL chr22 40346500 40390463 + AGRN chr1 1020120 1056118 + AHCY chr20 34280268 34311802 - AK2 chr1 33007940 33080996 - AKR1B1 chr7 134442356 134459284 - AKT1 chr14 104769349 104795751 - AL022238.4 chr22 40346529 40410054 + AL121758.1 chr20 646626 675800 - AL590764.2 chrX 71103987 71111575 - ALDH1B1 chr9 38392702 38398661 + ALDOA chr16 30064164 30070457 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC055860.1 chr11 18000542 18022931 - AC060780.1 chr17 43148368 43171037 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.