exRNAdisease

Entry Detail

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General Information

Database ID: exR0368268 RNA Name: PRRC2A RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 31620715 End Site(bp): 31637771 External Links: ENSG00000204469

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCB10 chr1 229516582 229558707 - ABHD16A chr6 31686955 31703356 - ABLIM1 chr10 114431113 114768061 - AC011448.1 chr19 19516227 19536076 + AC011462.1 chr19 41350853 41425001 + AC022384.1 chr3 10249372 10285796 + AC068580.4 chr11 1734821 1763954 - AC104109.3 chr5 134167170 134226071 - AC118549.1 chr1 77562416 77683419 - ACADVL chr17 7217125 7225266 + ACAP3 chr1 1292390 1309609 - ACTG1 chr17 81509971 81523847 - ACTR3 chr2 113890063 113962596 + ADIPOR1 chr1 202940826 202958572 - ADO chr10 62804720 62808479 + AGPAT5 chr8 6708642 6761503 + AHNAK chr11 62433542 62556235 - AIG1 chr6 143060496 143341058 + AKT1 chr14 104769349 104795751 - AKT2 chr19 40230317 40285536 - AL132780.3 chr14 22946270 22982258 - AL136295.5 chr14 24147548 24166452 + AL136454.1 chr1 192716132 192716653 + ALDH9A1 chr1 165662216 165698863 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004528.1 chr19 999796 1002757 - AC007406.5 chr12 273954 277123 - AC012236.1 chr15 31221999 31230838 - AC069185.1 chr8 11797928 11802568 - AC132217.1 chr11 2129121 2129964 - AD000090.1 chr19 35557956 35581954 + AGAP11 chr10 86970741 87010126 + AL136982.1 chr10 86992406 87010203 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.