exRNAdisease

Entry Detail

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General Information

Database ID: exR0369049 RNA Name: RPL10 RNA Type: mRNA Chromosome: chrX Starnd: + Coordinate: Start Site(bp): 154389955 End Site(bp): 154409168 External Links: ENSG00000147403

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCD4 chr14 74285269 74303055 - ABRACL chr6 139028745 139043302 + AC004832.3 chr22 30409255 30428990 + AC006064.6 chr12 6556886 6607367 - AC010132.3 chr7 42909273 42932174 - AC010422.3 chr19 12643831 12648397 - AC011455.2 chr19 38915404 38949855 - AC048338.1 chr12 122207779 122266423 - AC055811.2 chr17 17202649 17237185 - ACO2 chr22 41469117 41528989 + ACTB chr7 5527148 5563784 - ADAL chr15 43330657 43354555 + ADAR chr1 154582057 154628013 - ADD3 chr10 109996368 110135565 + ADSL chr22 40346500 40390463 + AEN chr15 88621337 88632281 + AGBL5 chr2 27042364 27070622 + AHCY chr20 34280268 34311802 - AK2 chr1 33007940 33080996 - AKR7A2 chr1 19303965 19312146 - AL022238.4 chr22 40346529 40410054 + AL133352.1 chr10 100505628 100529881 - AL136295.5 chr14 24147548 24166452 + AL590764.2 chrX 71103987 71111575 - ALAS1 chr3 52198086 52214327 + ALDH16A1 chr19 49453225 49471050 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-6891-3p chr6 31355228 31355248 - hsa-miR-7847-3p chr11 1880105 1880125 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002550.2 chr16 19694035 19694428 - AC060766.7 chr17 35406684 35409768 - AC092490.1 chr12 8788253 8795789 + AL035446.1 chr6 140845958 140852924 - AL121992.1 chr1 15586136 15603626 - AL132780.1 chr14 22929607 22956374 + AL138828.1 chr6 135991936 136225751 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.