exRNAdisease

Entry Detail

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General Information

Database ID: exR0369050 RNA Name: RPL10A RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 35468401 End Site(bp): 35470785 External Links: ENSG00000198755

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAAS chr12 53307456 53324864 - AAGAB chr15 67200667 67255195 - AAMP chr2 218264123 218270257 - ABLIM1 chr10 114431113 114768061 - AC004922.1 chr7 99325879 99394653 + AC007192.1 chr19 18153158 18178117 + AC011530.1 chr19 45779437 45785973 - AC040162.1 chr16 67929614 67936017 - AC069368.1 chr15 64841883 64930920 + AC087289.3 chr17 75898645 75930129 - AC090360.1 chr18 80034346 80097088 + AC091167.2 chr15 90249556 90272208 + AC105052.3 chr7 102637049 102671641 - AC119396.1 chr19 7348943 7383385 + ACACA chr17 37084992 37406836 - ACBD6 chr1 180269653 180502954 - ACTR2 chr2 65227753 65271253 + ADD3 chr10 109996368 110135565 + ADSL chr22 40346500 40390463 + AGBL5 chr2 27042364 27070622 + AHCYL1 chr1 109984765 110023742 + AKAP13 chr15 85380571 85749358 + AKNA chr9 114334156 114394405 - AL022238.4 chr22 40346529 40410054 + AL136454.1 chr1 192716132 192716653 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-7111-5p chr6 35470509 35470530 + hsa-miR-7111-3p chr6 35470558 35470579 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC012615.1 chr19 1874871 1876169 - AC020663.1 chr16 4730115 4752565 - AC023509.1 chr12 53441741 53467528 + AC063949.2 chr12 92421531 92483680 + AC067930.3 chr8 143541973 143549729 - AC126365.1 chr17 20788071 20789584 + AC132217.1 chr11 2129121 2129964 - AL022311.1 chr22 37876148 37895563 + AL110115.2 chr20 31580890 31581214 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.