exRNAdisease

Entry Detail

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General Information

Database ID: exR0369051 RNA Name: RPL11 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 23691742 End Site(bp): 23696835 External Links: ENSG00000142676

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AFDN chr6 167826922 167972023 + AC139530.2 chr17 81703371 81720539 + AIF1L chr9 131096476 131123152 + AKNA chr9 114334156 114394405 - AIMP2 chr7 6009255 6023834 + ADORA2A chr22 24417879 24442357 + ACTG1 chr17 81509971 81523847 - AIDA chr1 222668013 222713210 - ABCA3 chr16 2275881 2340746 - ABL2 chr1 179099330 179229684 - ACAA1 chr3 38103129 38137242 - AKIRIN1 chr1 38991276 39006059 + ACTR3 chr2 113890063 113962596 + ACP1 chr2 264140 278283 + AAAS chr12 53307456 53324864 - ADD2 chr2 70607618 70768225 - AKR1B1 chr7 134442356 134459284 - ACIN1 chr14 23058564 23095614 - ABHD12 chr20 25294742 25390835 - AC091167.2 chr15 90249556 90272208 + AC245033.1 chr15 82536788 82573194 - AC007192.1 chr19 18153158 18178117 + ALDOA chr16 30064164 30070457 + ALDH4A1 chr1 18871430 18902724 - AC010422.3 chr19 12643831 12648397 - AC008770.2 chr19 11925075 11979290 + ABRACL chr6 139028745 139043302 + ADM2 chr22 50481543 50486440 + ADGRG1 chr16 57610652 57665580 + ACTA1 chr1 229431245 229434098 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005083.1 chr7 20217577 20221700 + AC016876.2 chr17 7581964 7584086 - AC040162.3 chr16 67882461 67886367 + AC091564.7 chr11 6610883 6616594 - AC092910.3 chr3 120094895 120136783 + AC096992.2 chr3 136837338 136839021 - AC104793.1 chr4 161378953 161388417 + AC105339.2 chr15 82752884 82757208 + AC108010.1 chr7 128574751 128626473 + AC245014.3 chr1 145281116 145281462 + AC245033.4 chr15 82533175 82540008 - AL022311.1 chr22 37876148 37895563 + AL023653.1 chrX 129794994 129796963 + AL118516.1 chr22 46761894 46762563 - AL133243.2 chr2 32521927 32523547 + AL137782.1 chr13 75549773 75807120 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.