exRNAdisease

Entry Detail

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General Information

Database ID: exR0369053 RNA Name: RPL13 RNA Type: mRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 89560657 End Site(bp): 89566828 External Links: ENSG00000167526

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AGFG2 chr7 100539203 100568220 + AC009690.1 chr15 72284727 72375981 - ADO chr10 62804720 62808479 + AC008763.2 chr19 7629796 7643048 + ALDH5A1 chr6 24494867 24537207 + AK4 chr1 65147549 65232145 + AGAP1 chr2 235494043 236131800 + AAAS chr12 53307456 53324864 - AL136454.1 chr1 192716132 192716653 + AL590132.1 chr1 210858125 211134146 - ACTB chr7 5527148 5563784 - AC011455.2 chr19 38915404 38949855 - ACAT2 chr6 159762045 159779112 + ABCD3 chr1 94418389 94518666 + AHCYL1 chr1 109984765 110023742 + AK2 chr1 33007940 33080996 - ACP1 chr2 264140 278283 + AC004922.1 chr7 99325879 99394653 + ADPRHL2 chr1 36088892 36093932 + AARS2 chr6 44298731 44313347 - AC006030.1 chr2 74211604 74363377 - AIFM2 chr10 70098223 70132934 - ACADM chr1 75724347 75787575 + AC026464.4 chr16 69299682 69322700 + ADCY3 chr2 24819169 24919839 - ACTR3 chr2 113890063 113962596 + ADPGK chr15 72751369 72785846 - ACOT7 chr1 6264269 6394391 - AKIRIN1 chr1 38991276 39006059 + ALDH2 chr12 111766887 111817532 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-29c-3p chr1 207801865 207801886 - hsa-miR-4426 chr1 192716333 192716349 + hsa-miR-4485-3p chr11 10508277 10508296 - hsa-miR-4521 chr17 8186948 8186969 + hsa-miR-6716-3p chr11 118644048 118644069 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002116.1 chr19 36008638 36014235 - AC007952.4 chr17 19112000 19112636 - AC009022.1 chr16 69976297 70065948 - AC010542.4 chr16 66549280 66551189 + AC011632.1 chr8 74798784 74866939 - AC016747.1 chr2 61141592 61144969 - AC020928.2 chr19 36773712 36775908 - AC026362.1 chr12 122975320 122982907 + AC026401.3 chr16 15701237 15702118 + AC068768.1 chr12 123262060 123262402 + AC091564.7 chr11 6610883 6616594 - AC092143.3 chr16 89906157 89918233 + AC100810.1 chr8 1761054 1764508 - AC132217.1 chr11 2129121 2129964 - AC133644.3 chr2 87455476 87767359 + AC139149.1 chr17 81514047 81527776 + AC215522.2 chr7 19018 35489 - AC245014.3 chr1 145281116 145281462 + AC245033.4 chr15 82533175 82540008 - AD000090.1 chr19 35557956 35581954 + AF106564.1 chr8 24912165 24914717 - AL022311.1 chr22 37876148 37895563 + AL022341.1 chr16 648473 649200 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.