exRNAdisease

Entry Detail

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General Information

Database ID: exR0369059 RNA Name: RPL18 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 48615328 End Site(bp): 48619184 External Links: ENSG00000063177

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AKIRIN2 chr6 87674860 87702233 - ADAM9 chr8 38996869 39105261 + AC015813.2 chr17 57989038 58007246 - AC087289.3 chr17 75898645 75930129 - AC004922.1 chr7 99325879 99394653 + ACO2 chr22 41469117 41528989 + AIF1L chr9 131096476 131123152 + AC092143.1 chr16 89919165 89936092 + ABHD12 chr20 25294742 25390835 - ACTG1 chr17 81509971 81523847 - AGPAT1 chr6 32168212 32178096 - AEN chr15 88621337 88632281 + AACS chr12 125065434 125143333 + AL021546.1 chr12 120438198 120460006 + AL133352.1 chr10 100505628 100529881 - ADNP chr20 50888916 50931437 - ACVR1B chr12 51951699 51997078 + AC010132.3 chr7 42909273 42932174 - ACLY chr17 41866917 41930542 - AC010422.3 chr19 12643831 12648397 - ACOT2 chr14 73567620 73575658 + AC093525.2 chr16 2496032 2520218 + AHCTF1 chr1 246839098 246931967 - AC079594.2 chr3 160227454 160449829 - AC068580.4 chr11 1734821 1763954 - ALDH9A1 chr1 165662216 165698863 - ACTN4 chr19 38647649 38731589 + AGO1 chr1 35869808 35930532 + ALDH18A1 chr10 95605941 95656711 - ADM chr11 10305073 10307397 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005519.1 chr14 74289127 74294425 - AC006064.5 chr12 6510275 6510522 + AC007569.1 chr12 108628668 108642349 + AC010733.2 chr2 60925909 60931610 + AC011467.3 chr19 22603269 22608501 + AC016876.2 chr17 7581964 7584086 - AC020928.2 chr19 36773712 36775908 - AC022154.1 chr19 48619272 48624132 - AC023509.1 chr12 53441741 53467528 + AC067930.1 chr8 143579636 143580670 + AC090204.1 chr8 32927913 33045445 + AC095055.1 chr4 151139991 151141103 + AC132217.1 chr11 2129121 2129964 - AD000090.1 chr19 35557956 35581954 + AL031282.2 chr1 1702736 1737688 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.