exRNAdisease

Entry Detail

---



General Information

Database ID: exR0369079 RNA Name: RPL35 RNA Type: mRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 124857880 End Site(bp): 124861981 External Links: ENSG00000136942

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AAR2 chr20 36236459 36270918 + AC002985.1 chr19 18907013 18934397 - AC005258.1 chr19 2269525 2341172 + AC010323.1 chr19 8308283 8321379 - AC010422.3 chr19 12643831 12648397 - AC040162.1 chr16 67929614 67936017 - AC093525.1 chr16 2513965 2527955 + AC099811.2 chr17 42119674 42154916 - AC105052.1 chr7 102582523 102642869 - AC120057.2 chr17 7240427 7244635 - ACACA chr17 37084992 37406836 - ACCS chr11 44065925 44084237 + ACIN1 chr14 23058564 23095614 - ACLY chr17 41866917 41930542 - ACOT7 chr1 6264269 6394391 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ADCK2 chr7 140672945 140696261 + ADD1 chr4 2843857 2930076 + ADPGK chr15 72751369 72785846 - ADSL chr22 40346500 40390463 + AFG3L2 chr18 12328944 12377227 - AGBL5 chr2 27042364 27070622 + AHCY chr20 34280268 34311802 - AL022238.4 chr22 40346529 40410054 + AL136531.2 chr20 1317571 1393096 - AL928654.3 chr14 105487199 105492267 + ALDH7A1 chr5 126531200 126595362 - ALDOA chr16 30064164 30070457 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC026362.1 chr12 122975320 122982907 + AC068473.5 chr18 79677287 79679358 - AC105036.3 chr15 75527150 75601205 - AL021707.1 chr22 38739003 38749041 + AL022311.1 chr22 37876148 37895563 + AL138963.1 chr13 45350323 45351350 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.