exRNAdisease

Entry Detail

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General Information

Database ID: exR0369085 RNA Name: RPL37A RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 216498825 End Site(bp): 216579180 External Links: ENSG00000197756

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC015813.2 chr17 57989038 58007246 - AK2 chr1 33007940 33080996 - AL136295.5 chr14 24147548 24166452 + AC068547.1 chr2 151802651 151973949 - ACTN4 chr19 38647649 38731589 + AC007192.1 chr19 18153158 18178117 + ADGRL2 chr1 81306160 81992436 + AC124312.1 chr15 24955034 25000276 + ACTB chr7 5527148 5563784 - AL136295.1 chr14 24189157 24213473 - AATF chr17 36948954 37056871 + AC068580.4 chr11 1734821 1763954 - AKIRIN1 chr1 38991276 39006059 + ADPRH chr3 119579268 119589945 + AL139011.2 chr1 160216800 160285130 - AC093827.5 chr4 86886472 86936178 - ABRACL chr6 139028745 139043302 + ABT1 chr6 26596953 26600739 + ACTR3 chr2 113890063 113962596 + AC092718.8 chr16 81022316 81096284 - AKIRIN2 chr6 87674860 87702233 - AC073508.2 chr17 40627356 40665141 - ALDH7A1 chr5 126531200 126595362 - AL133352.1 chr10 100505628 100529881 - AL049844.3 chr6 143857318 143938471 + ADD1 chr4 2843857 2930076 + ADAMTS3 chr4 72280969 72569221 - AC092718.3 chr16 81053587 81096296 - ADAL chr15 43330657 43354555 + ABCE1 chr4 145098288 145129524 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-155-3p chr21 25574022 25574043 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010729.1 chr2 5726253 5730355 + AC016747.4 chr2 61115787 61164825 + AC016876.2 chr17 7581964 7584086 - AC020978.7 chr16 68224713 68227734 + AC023509.1 chr12 53441741 53467528 + AC040934.1 chr17 47409322 47423526 - AC073321.1 chr2 216594359 216611206 + AC093827.4 chr4 86924630 86936202 - AC105105.1 chr18 58535415 58538552 + AC106739.1 chr16 27313387 27314101 - AL096870.2 chr14 24209646 24215987 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.