exRNAdisease

Entry Detail

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General Information

Database ID: exR0369096 RNA Name: RPL8 RNA Type: mRNA Chromosome: chr8 Starnd: - Coordinate: Start Site(bp): 144789765 End Site(bp): 144792587 External Links: ENSG00000161016

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AHCY chr20 34280268 34311802 - ALDOA chr16 30064164 30070457 + AC124312.1 chr15 24955034 25000276 + ACTB chr7 5527148 5563784 - AC105052.3 chr7 102637049 102671641 - ALDH6A1 chr14 74056847 74084492 - ADCK1 chr14 77800109 77935014 + AC004922.1 chr7 99325879 99394653 + ACTN1 chr14 68874143 68979440 - AKIRIN1 chr1 38991276 39006059 + AC092073.1 chr19 34396315 34409364 + ADARB2 chr10 1177313 1737525 - AIMP2 chr7 6009255 6023834 + ACTN4 chr19 38647649 38731589 + AC008982.1 chr19 38817471 38840178 - AHSA1 chr14 77457870 77469472 + ABHD12 chr20 25294742 25390835 - AC027796.3 chr17 3585149 3636249 - ACTG1 chr17 81509971 81523847 - ACACA chr17 37084992 37406836 - ACTR5 chr20 38748460 38772520 + ACTR2 chr2 65227753 65271253 + AKAP8L chr19 15380050 15419141 - ADNP chr20 50888916 50931437 - AC011448.1 chr19 19516227 19536076 + AL022238.4 chr22 40346529 40410054 + AC018523.2 chr11 14493783 14520344 - AGA chr4 177430774 177442437 - AC020909.1 chr19 50415799 50428409 + ABHD17A chr19 1876810 1885547 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4751 chr19 49933073 49933096 + hsa-miR-6850-5p chr8 144791970 144791991 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005899.4 chr17 32328441 32329395 + AC007952.4 chr17 19112000 19112636 - AC016876.2 chr17 7581964 7584086 - AC021242.3 chr8 9555144 9556520 - AC026362.1 chr12 122975320 122982907 + AC026461.1 chr16 56682470 56687807 + AC060780.1 chr17 43148368 43171037 - AC067930.1 chr8 143579636 143580670 + AC092329.1 chr19 23257255 23274232 - AC092329.4 chr19 23259906 23274251 - AC099778.1 chr3 47379089 47380999 - AC105105.1 chr18 58535415 58538552 + AC105285.1 chr4 173094868 173169652 - AC132217.1 chr11 2129121 2129964 - AD000090.1 chr19 35557956 35581954 + AL021707.1 chr22 38739003 38749041 + AL022311.1 chr22 37876148 37895563 + AL132780.1 chr14 22929607 22956374 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.