exRNAdisease

Entry Detail

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General Information

Database ID: exR0369098 RNA Name: RPLP0 RNA Type: mRNA Chromosome: chr12 Starnd: - Coordinate: Start Site(bp): 120196699 End Site(bp): 120201235 External Links: ENSG00000089157

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092718.3 chr16 81053587 81096296 - AC007192.1 chr19 18153158 18178117 + AC091167.2 chr15 90249556 90272208 + AC138811.2 chr16 18788063 18801519 - ACTR3 chr2 113890063 113962596 + ADGRA3 chr4 22345071 22516066 - ACTR5 chr20 38748460 38772520 + AL121594.1 chr14 35122549 35317474 + AGPAT5 chr8 6708642 6761503 + AARS2 chr6 44298731 44313347 - AGPAT3 chr21 43865223 43987592 + AL132671.2 chr6 117318211 117573571 - AC010422.3 chr19 12643831 12648397 - AL022238.4 chr22 40346529 40410054 + AK3 chr9 4709556 4742043 - ADNP chr20 50888916 50931437 - AC010323.1 chr19 8308283 8321379 - ABCF1 chr6 30571393 30597179 + AHCYL1 chr1 109984765 110023742 + AC011455.2 chr19 38915404 38949855 - AL136295.1 chr14 24189157 24213473 - AC011511.1 chr19 10305427 10316009 - AC006064.6 chr12 6556886 6607367 - AC005832.4 chr12 4604944 4662643 + ACTG1 chr17 81509971 81523847 - AC010463.1 chr19 17267418 17282966 + AL133352.1 chr10 100505628 100529881 - AKT1 chr14 104769349 104795751 - AL928654.3 chr14 105487199 105492267 + ACAT1 chr11 108116695 108147603 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3609 chr7 98881700 98881723 + hsa-miR-4426 chr1 192716333 192716349 + hsa-miR-6833-3p chr6 32179856 32179876 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002470.2 chr22 20979462 20998121 + AC007952.4 chr17 19112000 19112636 - AC008937.3 chr5 56927874 56929573 + AC010542.4 chr16 66549280 66551189 + AC010642.2 chr19 58309727 58327248 - AC010655.2 chr7 128455937 128469197 + AC010655.4 chr7 128455840 128493859 + AC010733.2 chr2 60925909 60931610 + AC020910.5 chr19 34733298 34733837 - AC023509.1 chr12 53441741 53467528 + AC026362.1 chr12 122975320 122982907 + AC064802.1 chr8 114282067 114295839 + AC068768.1 chr12 123262060 123262402 + AC073896.4 chr12 56162359 56190284 - AC104109.4 chr5 134205614 134371044 - AC105036.3 chr15 75527150 75601205 - AC109460.3 chr16 28974804 28990775 + AC147651.4 chr7 603185 608482 + AD000090.1 chr19 35557956 35581954 + ADD3-AS1 chr10 109940104 110008381 - AL022311.1 chr22 37876148 37895563 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.