exRNAdisease

Entry Detail

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General Information

Database ID: exR0369099 RNA Name: RPLP1 RNA Type: mRNA Chromosome: chr15 Starnd: + Coordinate: Start Site(bp): 69452814 End Site(bp): 69456205 External Links: ENSG00000137818

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC245033.1 chr15 82536788 82573194 - ACOT9 chrX 23701055 23766475 - AC004922.1 chr7 99325879 99394653 + AFAP1L2 chr10 114294824 114404756 - AGO3 chr1 35930718 36072500 + ACTC1 chr15 34790230 34795549 - AIG1 chr6 143060496 143341058 + AGPAT1 chr6 32168212 32178096 - ACTB chr7 5527148 5563784 - AHSA1 chr14 77457870 77469472 + ADGRA3 chr4 22345071 22516066 - ADRM1 chr20 62302093 62308862 + AIFM1 chrX 130129362 130165887 - ACADS chr12 120725774 120740008 + ABHD5 chr3 43690108 43734371 + ADA chr20 44619522 44652233 - ACAA2 chr18 49782164 49813953 - AC092143.1 chr16 89919165 89936092 + AGPAT5 chr8 6708642 6761503 + AL133352.1 chr10 100505628 100529881 - AFF4 chr5 132875395 132963634 - ADH5 chr4 99070978 99088801 - AC023055.1 chr12 55757275 55827546 - AC007192.1 chr19 18153158 18178117 + AEBP2 chr12 19404045 19720801 + AC118549.1 chr1 77562416 77683419 - AC090517.4 chr15 56652488 56918571 - AC010132.3 chr7 42909273 42932174 - AGPAT3 chr21 43865223 43987592 + AC010422.3 chr19 12643831 12648397 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-302b-3p chr4 112648489 112648511 - hsa-miR-3917 chr1 25906384 25906403 - hsa-miR-4426 chr1 192716333 192716349 + hsa-miR-4707-5p chr14 22956998 22957020 - hsa-miR-4707-3p chr14 22956957 22956978 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC004951.4 chr7 43951910 44019151 - AC005618.1 chr5 141326210 141329357 + AC007613.1 chr16 11741910 11744506 + AC009403.1 chr7 155611231 155645205 - AC009403.2 chr7 155474256 155644406 - AC020928.2 chr19 36773712 36775908 - AC022400.3 chr10 73674295 73730466 - AC022400.5 chr10 73699151 73730487 - AC060780.1 chr17 43148368 43171037 - AC104793.1 chr4 161378953 161388417 + AC245014.3 chr1 145281116 145281462 + AL049795.2 chr1 32170733 32176568 + AL117378.1 chr6 131901963 131920565 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.