exRNAdisease

Entry Detail

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General Information

Database ID: exR0369100 RNA Name: RPLP2 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 809965 End Site(bp): 812880 External Links: ENSG00000177600

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010646.1 chr19 17235940 17255448 - ALDOA chr16 30064164 30070457 + AL139300.1 chr14 103562962 103685924 + AC011455.2 chr19 38915404 38949855 - AGO4 chr1 35808016 35857890 + AKAP1 chr17 57085092 57121346 + AC007192.1 chr19 18153158 18178117 + AC135050.2 chr16 31083439 31094956 - ADGRL2 chr1 81306160 81992436 + AC010422.3 chr19 12643831 12648397 - AC020915.5 chr19 58228914 58315183 + AKT2 chr19 40230317 40285536 - AFTPH chr2 64524305 64593005 + ACIN1 chr14 23058564 23095614 - AIFM1 chrX 130129362 130165887 - AC004922.1 chr7 99325879 99394653 + AL049629.2 chr11 33698261 33722467 - ADCY1 chr7 45574140 45723116 + ACTG1 chr17 81509971 81523847 - AFDN chr6 167826922 167972023 + AC005258.1 chr19 2269525 2341172 + ADRM1 chr20 62302093 62308862 + AL121594.1 chr14 35122549 35317474 + ALDH18A1 chr10 95605941 95656711 - AGRN chr1 1020120 1056118 + ADH5 chr4 99070978 99088801 - AACS chr12 125065434 125143333 + AGBL5 chr2 27042364 27070622 + ABCF1 chr6 30571393 30597179 + AC008878.3 chr19 7382834 7470241 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-7705 chr8 100703002 100703024 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007780.1 chr17 68413623 68524949 + AC017104.1 chr2 231388976 231394991 + AC018521.1 chr17 47945424 47981736 + AC026362.1 chr12 122975320 122982907 + AD000090.1 chr19 35557956 35581954 + AL137782.1 chr13 75549773 75807120 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.