exRNAdisease

Entry Detail

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General Information

Database ID: exR0369117 RNA Name: RPS14 RNA Type: mRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 150442635 End Site(bp): 150449739 External Links: ENSG00000164587

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC068580.4 chr11 1734821 1763954 - ALDOA chr16 30064164 30070457 + ACTG1 chr17 81509971 81523847 - ACTB chr7 5527148 5563784 - ADSL chr22 40346500 40390463 + AL136295.1 chr14 24189157 24213473 - ABLIM1 chr10 114431113 114768061 - AHCYL1 chr1 109984765 110023742 + ALDH2 chr12 111766887 111817532 + ADARB1 chr21 45073853 45226560 + AC004922.1 chr7 99325879 99394653 + AC009133.6 chr16 29812261 29820092 + AASS chr7 122073549 122144255 - ACSL4 chrX 109624244 109733403 - AFAP1 chr4 7758714 7939926 - AL136295.4 chr14 24180395 24190416 - AHCYL2 chr7 129225023 129430211 + AL160269.1 chr9 96235331 96352058 - ADI1 chr2 3497366 3519531 - ACTR3 chr2 113890063 113962596 + ADGRE5 chr19 14380501 14408725 + AL513165.2 chr9 37512547 37592469 - AKAP1 chr17 57085092 57121346 + AC026954.2 chr17 7312661 7319174 - AL162417.1 chr9 133098121 133163914 - AKAP17A chrX 1591604 1602520 + AL133352.1 chr10 100505628 100529881 - ADPGK chr15 72751369 72785846 - AC027796.3 chr17 3585149 3636249 - AC004832.3 chr22 30409255 30428990 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-3654 chr7 133034860 133034878 - hsa-miR-6891-3p chr6 31355228 31355248 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC010642.2 chr19 58309727 58327248 - AC013268.5 chr2 109937438 109985124 + AC018521.5 chr17 47891229 47895812 - AC024940.6 chr12 31280422 31280895 - AC040162.3 chr16 67882461 67886367 + AC063949.2 chr12 92421531 92483680 + AC104109.4 chr5 134205614 134371044 - AC125257.1 chr17 41848518 41851447 - AC132217.1 chr11 2129121 2129964 - AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.