exRNAdisease

Entry Detail

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General Information

Database ID: exR0369120 RNA Name: RPS16 RNA Type: mRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 39433137 End Site(bp): 39435949 External Links: ENSG00000105193

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AL928654.3 chr14 105487199 105492267 + ACTA2 chr10 88935074 88991339 - ACOT9 chrX 23701055 23766475 - AC009690.1 chr15 72284727 72375981 - ACTN4 chr19 38647649 38731589 + ALDOA chr16 30064164 30070457 + ADORA2A chr22 24417879 24442357 + ACTL6A chr3 179562886 179588407 + AKAP5 chr14 64465499 64474503 + ADGRG6 chr6 142301854 142446266 + AC010422.3 chr19 12643831 12648397 - AICDA chr12 8602170 8612867 - AHSA1 chr14 77457870 77469472 + AL121845.2 chr20 63738270 63740398 + ACIN1 chr14 23058564 23095614 - AL121845.3 chr20 63708864 63739103 + ABCB8 chr7 151028422 151047782 + ADM chr11 10305073 10307397 + ADIPOR2 chr12 1688574 1788674 + ACO2 chr22 41469117 41528989 + AEN chr15 88621337 88632281 + ACAA2 chr18 49782164 49813953 - AC010323.1 chr19 8308283 8321379 - AHCY chr20 34280268 34311802 - ADI1 chr2 3497366 3519531 - AC004922.1 chr7 99325879 99394653 + ADD1 chr4 2843857 2930076 + ABCF1 chr6 30571393 30597179 + AC124312.1 chr15 24955034 25000276 + AK2 chr1 33007940 33080996 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-492 chr12 94834427 94834449 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + AC027020.2 chr15 100547765 100550153 - AC067852.1 chr17 42536510 42562062 + AC096536.3 chr1 54874672 54883664 + AC104596.1 chr4 142933195 143184861 - AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + AL132780.1 chr14 22929607 22956374 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.