exRNAdisease

Entry Detail

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General Information

Database ID: exR0369136 RNA Name: RPS3 RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 75399515 End Site(bp): 75422280 External Links: ENSG00000149273

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AL022238.4 chr22 40346529 40410054 + ADSL chr22 40346500 40390463 + AC007192.1 chr19 18153158 18178117 + ADAR chr1 154582057 154628013 - ADNP chr20 50888916 50931437 - AK4 chr1 65147549 65232145 + ADPGK chr15 72751369 72785846 - AL136454.1 chr1 192716132 192716653 + ACIN1 chr14 23058564 23095614 - ACBD5 chr10 27195214 27242130 - AL928654.3 chr14 105487199 105492267 + AL133352.1 chr10 100505628 100529881 - ACO2 chr22 41469117 41528989 + AKAP1 chr17 57085092 57121346 + ACSL5 chr10 112374018 112428380 + AC008764.4 chr19 16577642 16660115 - AC068580.4 chr11 1734821 1763954 - AHSA1 chr14 77457870 77469472 + AKAP8L chr19 15380050 15419141 - ABCF2 chr7 151207837 151227166 - AGPAT1 chr6 32168212 32178096 - ADH5 chr4 99070978 99088801 - ACTB chr7 5527148 5563784 - AC002985.1 chr19 18907013 18934397 - AC004832.3 chr22 30409255 30428990 + ABCG2 chr4 88090150 88231628 - AK2 chr1 33007940 33080996 - AGRN chr1 1020120 1056118 + ADORA2A chr22 24417879 24442357 + AKNA chr9 114334156 114394405 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-92a-3p chrX 134169544 134169565 - hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-3654 chr7 133034860 133034878 - hsa-miR-4485-3p chr11 10508277 10508296 - hsa-miR-6728-3p chr1 8866502 8866522 - hsa-miR-6793-3p chr19 10829016 10829035 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004865.2 chr1 35569813 35577729 - AC005899.4 chr17 32328441 32329395 + AC007952.4 chr17 19112000 19112636 - AC009052.1 chr16 57461055 57462737 + AC016026.1 chr22 17787652 17811497 - AC016876.2 chr17 7581964 7584086 - AC018521.1 chr17 47945424 47981736 + AC019069.1 chr2 74832655 74833987 - AC022182.2 chr8 60965802 60967775 - AC023509.1 chr12 53441741 53467528 + AC026401.3 chr16 15701237 15702118 + AC067852.2 chr17 42552436 42554748 - AC069281.2 chr7 100572232 100578700 - AC079354.3 chr2 202137570 202149627 - AC103691.1 chr15 64950916 64951435 - AC106864.1 chr4 112693047 112706810 - AC108134.2 chr16 3156736 3157483 - AC116407.2 chr17 32127595 32128454 + AC139149.1 chr17 81514047 81527776 + AC139768.1 chr12 51201684 51202581 - AC245014.3 chr1 145281116 145281462 + AC245033.4 chr15 82533175 82540008 - AC245884.11 chr19 54308915 54337168 - AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL132780.1 chr14 22929607 22956374 + AL137230.2 chr14 89628921 89642671 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.