exRNAdisease

Entry Detail

---



General Information

Database ID: exR0369138 RNA Name: RPS4X RNA Type: mRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 72255679 End Site(bp): 72277248 External Links: ENSG00000198034

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AGPAT3 chr21 43865223 43987592 + ALDOA chr16 30064164 30070457 + ACSL3 chr2 222860942 222944639 + ADAR chr1 154582057 154628013 - ACAA1 chr3 38103129 38137242 - AL022238.4 chr22 40346529 40410054 + AL136454.1 chr1 192716132 192716653 + ADSL chr22 40346500 40390463 + AKAP13 chr15 85380571 85749358 + ADTRP chr6 11712054 11807046 - ADA2 chr22 17178790 17258235 - ABCF2 chr7 151207837 151227166 - AC026464.4 chr16 69299682 69322700 + AC011530.1 chr19 45779437 45785973 - AL590764.2 chrX 71103987 71111575 - AKR1A1 chr1 45550543 45570049 + AASS chr7 122073549 122144255 - AC245033.1 chr15 82536788 82573194 - ADRM1 chr20 62302093 62308862 + AC010422.3 chr19 12643831 12648397 - ACAD9 chr3 128879596 128916067 + ACKR3 chr2 236567787 236582354 + AC010132.3 chr7 42909273 42932174 - AC139530.2 chr17 81703371 81720539 + ACAT1 chr11 108116695 108147603 + AC120057.2 chr17 7240427 7244635 - ACTB chr7 5527148 5563784 - ACIN1 chr14 23058564 23095614 - AC104452.1 chr3 49416777 49429314 - ACTG1 chr17 81509971 81523847 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-3651 chr9 92292461 92292484 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006511.5 chr12 8014093 8019007 - AC016876.2 chr17 7581964 7584086 - AC020663.1 chr16 4730115 4752565 - AC023509.1 chr12 53441741 53467528 + AC087190.3 chr16 9104848 9113181 + AC091564.7 chr11 6610883 6616594 - AC107959.2 chr8 23068229 23083619 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL118506.1 chr20 63861212 63864293 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.