exRNAdisease

Entry Detail

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General Information

Database ID: exR0369153 RNA Name: RPS8 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 44775251 End Site(bp): 44778779 External Links: ENSG00000142937

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACVR1B chr12 51951699 51997078 + AL021546.1 chr12 120438198 120460006 + AC073508.2 chr17 40627356 40665141 - AC008758.1 chr19 12461559 12551474 - ACAT1 chr11 108116695 108147603 + AC120057.2 chr17 7240427 7244635 - AC138811.2 chr16 18788063 18801519 - ADNP chr20 50888916 50931437 - AHCYL1 chr1 109984765 110023742 + AGL chr1 99850361 99924023 + ABI3 chr17 49210411 49223225 + ACTG1 chr17 81509971 81523847 - ACTR1B chr2 97655939 97664044 - ACTA2 chr10 88935074 88991339 - AL136295.5 chr14 24147548 24166452 + ABRACL chr6 139028745 139043302 + AKIRIN1 chr1 38991276 39006059 + AKT1 chr14 104769349 104795751 - ACTA1 chr1 229431245 229434098 - AL669918.1 chr6 32813767 32838822 - AHRR chr5 271670 438291 + ABCD4 chr14 74285269 74303055 - AGPAT3 chr21 43865223 43987592 + AEN chr15 88621337 88632281 + AC002985.1 chr19 18907013 18934397 - AKR7A2 chr1 19303965 19312146 - ADRM1 chr20 62302093 62308862 + AC022384.1 chr3 10249372 10285796 + ADAR chr1 154582057 154628013 - ADD1 chr4 2843857 2930076 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-92a-3p chrX 134169544 134169565 - hsa-miR-367-3p chr4 112647877 112647898 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC063949.2 chr12 92421531 92483680 + AC090772.3 chr18 24159509 24162211 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.