exRNAdisease

Entry Detail

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General Information

Database ID: exR0369154 RNA Name: RPS9 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 54200809 End Site(bp): 54249003 External Links: ENSG00000170889

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADRM1 chr20 62302093 62308862 + AL021546.1 chr12 120438198 120460006 + ALDH16A1 chr19 49453225 49471050 + AC007192.1 chr19 18153158 18178117 + AHSA1 chr14 77457870 77469472 + ADGRG5 chr16 57542643 57591681 + AGAP4 chr10 45825594 45853875 - AC105052.3 chr7 102637049 102671641 - ABRACL chr6 139028745 139043302 + ADAM8 chr10 133262420 133276868 - AGGF1 chr5 77029251 77065234 + ADAM10 chr15 58588809 58749791 - ACTB chr7 5527148 5563784 - AKT1S1 chr19 49869033 49878459 - AC004922.1 chr7 99325879 99394653 + ACAA2 chr18 49782164 49813953 - AC120057.2 chr17 7240427 7244635 - AHCY chr20 34280268 34311802 - ACVR2B chr3 38453890 38493142 + AASDHPPT chr11 106075501 106098699 + ACER3 chr11 76860867 77026797 + ACOT2 chr14 73567620 73575658 + AC245033.1 chr15 82536788 82573194 - ABLIM1 chr10 114431113 114768061 - AC138811.2 chr16 18788063 18801519 - ADNP chr20 50888916 50931437 - AFDN chr6 167826922 167972023 + ABHD17B chr9 71862452 71910931 - AKNA chr9 114334156 114394405 - ACTG1 chr17 81509971 81523847 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3615 chr17 74748663 74748683 + hsa-miR-4707-5p chr14 22956998 22957020 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004069.1 chr4 105137280 105140619 - AC022400.3 chr10 73674295 73730466 - AC073508.3 chr17 40648300 40649718 + AC132217.1 chr11 2129121 2129964 - AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + AL139089.1 chr13 52651305 52652279 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.