exRNAdisease

Entry Detail

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General Information

Database ID: exR0369339 RNA Name: SCD RNA Type: mRNA Chromosome: chr10 Starnd: + Coordinate: Start Site(bp): 100347233 End Site(bp): 100364826 External Links: ENSG00000099194

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010132.3 chr7 42909273 42932174 - AC018523.2 chr11 14493783 14520344 - AC048338.1 chr12 122207779 122266423 - AC092143.1 chr16 89919165 89936092 + AC120057.2 chr17 7240427 7244635 - AC138811.2 chr16 18788063 18801519 - ACP1 chr2 264140 278283 + ACP6 chr1 147629652 147670524 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTR2 chr2 65227753 65271253 + ADAR chr1 154582057 154628013 - ADSL chr22 40346500 40390463 + AEBP2 chr12 19404045 19720801 + AGBL5 chr2 27042364 27070622 + AGPS chr2 177392757 177559299 + AIG1 chr6 143060496 143341058 + AKIRIN2 chr6 87674860 87702233 - AL022238.4 chr22 40346529 40410054 + ALDH7A1 chr5 126531200 126595362 - ALDH9A1 chr1 165662216 165698863 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-7-5p chr19 4770700 4770723 + hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-1321 chrX 85835832 85835849 + hsa-miR-1197 chr14 101025620 101025640 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004816.1 chr14 70809841 70815994 + AC005618.1 chr5 141326210 141329357 + AC009446.1 chr8 71675300 71702786 + AC010719.1 chr7 25948657 25949403 - AC106795.2 chr5 177950335 177963960 + AC106864.1 chr4 112693047 112706810 - AC124068.2 chr15 89335053 89336161 + AC124283.3 chr17 82578023 82578616 + AC126365.1 chr17 20788071 20789584 + AL132780.1 chr14 22929607 22956374 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.