exRNAdisease

Entry Detail

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General Information

Database ID: exR0369474 RNA Name: SERBP1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 67407810 End Site(bp): 67430415 External Links: ENSG00000142864

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCB7 chrX 75051048 75156732 - ABLIM1 chr10 114431113 114768061 - AC007192.1 chr19 18153158 18178117 + AC008763.3 chr19 7678501 7682854 + AC010422.3 chr19 12643831 12648397 - AC011511.4 chr19 10315471 10320678 - AC093525.2 chr16 2496032 2520218 + AC112229.3 chr2 110402934 110473075 - AC135050.2 chr16 31083439 31094956 - AC245033.1 chr15 82536788 82573194 - ACAD8 chr11 134253495 134265855 + ACTA1 chr1 229431245 229434098 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - AD000671.2 chr19 35739252 35745432 - ADAR chr1 154582057 154628013 - ADCY6 chr12 48766194 48789037 - ADD3 chr10 109996368 110135565 + ADSL chr22 40346500 40390463 + AGBL5 chr2 27042364 27070622 + AHCYL1 chr1 109984765 110023742 + AKAP1 chr17 57085092 57121346 + AKR7A3 chr1 19282573 19288770 - AL022238.4 chr22 40346529 40410054 + AL109827.1 chr20 35632340 35674544 - AL136295.5 chr14 24147548 24166452 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-526b-5p chr19 53694406 53694428 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC010327.5 chr19 55216660 55221616 + AC022148.1 chr19 37545470 37549171 - AC023509.1 chr12 53441741 53467528 + AC245014.3 chr1 145281116 145281462 + AC245033.4 chr15 82533175 82540008 - AD000090.1 chr19 35557956 35581954 + AL133520.1 chr20 46681676 46682375 - AL137026.2 chr10 44259602 44261813 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.