exRNAdisease

Entry Detail

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General Information

Database ID: exR0370347 RNA Name: SREBF2 RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 41833079 End Site(bp): 41907307 External Links: ENSG00000198911

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AATF chr17 36948954 37056871 + ABCG2 chr4 88090150 88231628 - AC005258.1 chr19 2269525 2341172 + AC010422.3 chr19 12643831 12648397 - AC015813.2 chr17 57989038 58007246 - AC087289.3 chr17 75898645 75930129 - AC118549.1 chr1 77562416 77683419 - AC245033.1 chr15 82536788 82573194 - ACLY chr17 41866917 41930542 - ACO2 chr22 41469117 41528989 + ACSS3 chr12 80936414 81261210 + ACTB chr7 5527148 5563784 - ACTN1 chr14 68874143 68979440 - ADD2 chr2 70607618 70768225 - ADGRG6 chr6 142301854 142446266 + ADRM1 chr20 62302093 62308862 + AFDN chr6 167826922 167972023 + AGO2 chr8 140520156 140635633 - AKIRIN1 chr1 38991276 39006059 + AKIRIN2 chr6 87674860 87702233 - AL645941.2 chr6 32937364 32953122 - ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-185-5p chr22 20033153 20033174 + hsa-miR-625-5p chr14 65471116 65471136 + hsa-miR-650 chr22 22822791 22822811 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-33a-3p chr22 41900989 41901010 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC026362.1 chr12 122975320 122982907 + AC064807.1 chr8 51899268 51949874 + AC078846.1 chr7 129604548 129611630 - AC106864.1 chr4 112693047 112706810 - AC132217.1 chr11 2129121 2129964 - AC135048.1 chr16 30948386 30956511 + AC138035.2 chr5 181329241 181342213 + AC245033.4 chr15 82533175 82540008 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.