exRNAdisease

Entry Detail

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General Information

Database ID: exR0370372 RNA Name: SRRM2 RNA Type: mRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 2752626 End Site(bp): 2772538 External Links: ENSG00000167978

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCA2 chr9 137007234 137028922 - ABCB8 chr7 151028422 151047782 + ABCG2 chr4 88090150 88231628 - ABI1 chr10 26746593 26861087 - ABT1 chr6 26596953 26600739 + AC010422.3 chr19 12643831 12648397 - AC046185.1 chr17 63702845 63752097 - AC092143.1 chr16 89919165 89936092 + AC093525.1 chr16 2513965 2527955 + AC104452.1 chr3 49416777 49429314 - AC107871.1 chr15 68184032 68229718 - AC120057.2 chr17 7240427 7244635 - AC138811.2 chr16 18788063 18801519 - ACTB chr7 5527148 5563784 - ACTN4 chr19 38647649 38731589 + ADAM10 chr15 58588809 58749791 - ADAM15 chr1 155050566 155062775 + ADGRE5 chr19 14380501 14408725 + ADGRL2 chr1 81306160 81992436 + ADRM1 chr20 62302093 62308862 + AGGF1 chr5 77029251 77065234 + AGPAT1 chr6 32168212 32178096 - AHNAK chr11 62433542 62556235 - AK4 chr1 65147549 65232145 + AKT2 chr19 40230317 40285536 - ALDH18A1 chr10 95605941 95656711 - ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3648 chr21 8987026 8987046 + hsa-miR-7847-3p chr11 1880105 1880125 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005696.4 chr17 2720801 2723947 - AC007952.4 chr17 19112000 19112636 - AC016876.2 chr17 7581964 7584086 - AC020663.1 chr16 4730115 4752565 - AC026362.1 chr12 122975320 122982907 + AC051619.7 chr15 45200325 45200632 - AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.