exRNAdisease

Entry Detail

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General Information

Database ID: exR0371009 RNA Name: TKT RNA Type: mRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 53224712 End Site(bp): 53256052 External Links: ENSG00000163931

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCF1 chr6 30571393 30597179 + AC104532.1 chr19 5904841 5914707 + AC245033.1 chr15 82536788 82573194 - AC124312.1 chr15 24955034 25000276 + AC008982.1 chr19 38817471 38840178 - ACTR1A chr10 102461881 102502712 - ALDOA chr16 30064164 30070457 + ACO2 chr22 41469117 41528989 + ACAP1 chr17 7336529 7351477 + ABCA2 chr9 137007234 137028922 - AC104109.3 chr5 134167170 134226071 - ACLY chr17 41866917 41930542 - AC004922.1 chr7 99325879 99394653 + AC068580.4 chr11 1734821 1763954 - AL136454.1 chr1 192716132 192716653 + AD000671.2 chr19 35739252 35745432 - AGO4 chr1 35808016 35857890 + AC138969.1 chr16 16317444 16350590 + ACTB chr7 5527148 5563784 - AC007192.1 chr19 18153158 18178117 + ADAR chr1 154582057 154628013 - ACTG1 chr17 81509971 81523847 - AKT1 chr14 104769349 104795751 - AC010615.4 chr19 21405159 21491266 + AC018523.2 chr11 14493783 14520344 - AC004832.3 chr22 30409255 30428990 + ADSL chr22 40346500 40390463 + AKAP12 chr6 151239967 151358559 + AL022238.4 chr22 40346529 40410054 + ADRM1 chr20 62302093 62308862 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC012236.1 chr15 31221999 31230838 - AC087521.3 chr11 43921059 44001157 + AC091564.7 chr11 6610883 6616594 - AC091729.3 chr7 1160374 1165607 + AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + AL031282.2 chr1 1702736 1737688 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.