exRNAdisease

Entry Detail

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General Information

Database ID: exR0371048 RNA Name: TMBIM6 RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 49707725 End Site(bp): 49764934 External Links: ENSG00000139644

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AKAP12 chr6 151239967 151358559 + AGA chr4 177430774 177442437 - ACTB chr7 5527148 5563784 - AATF chr17 36948954 37056871 + ACBD5 chr10 27195214 27242130 - ADAMTS1 chr21 26835755 26845409 - AL353588.1 chr6 44273194 44378957 + AC092647.5 chr7 55887277 55955239 + AC026464.4 chr16 69299682 69322700 + AGO2 chr8 140520156 140635633 - ABCG2 chr4 88090150 88231628 - AFF1 chr4 86935002 87141054 + AC004997.1 chr22 30285238 30299482 - AL139353.1 chr14 31334312 31457441 - AC048338.1 chr12 122207779 122266423 - AIF1L chr9 131096476 131123152 + AC078927.1 chr12 66123917 66169985 - ACSF2 chr17 50426158 50474845 + ADAM22 chr7 87934143 88202889 + ABHD8 chr19 17292131 17310236 - ALDOA chr16 30064164 30070457 + ACTG1 chr17 81509971 81523847 - AHCY chr20 34280268 34311802 - ACO2 chr22 41469117 41528989 + AC010422.3 chr19 12643831 12648397 - AASDHPPT chr11 106075501 106098699 + ACTL6A chr3 179562886 179588407 + AL162417.1 chr9 133098121 133163914 - AHNAK chr11 62433542 62556235 - ADRM1 chr20 62302093 62308862 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-423-5p chr17 30117095 30117117 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009446.1 chr8 71675300 71702786 + AC012360.3 chr2 105334027 105337475 - AC018521.1 chr17 47945424 47981736 + AC020978.7 chr16 68224713 68227734 + AC022140.1 chr5 25404733 25445925 - AC023509.1 chr12 53441741 53467528 + AD000090.1 chr19 35557956 35581954 + AF129075.2 chr21 29058073 29060095 - AL021707.3 chr22 38734730 38738990 + AL049543.1 chr6 28587378 28591747 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.