exRNAdisease

Entry Detail

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General Information

Database ID: exR0371383 RNA Name: TPI1 RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 6867119 End Site(bp): 6870948 External Links: ENSG00000111669

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADAMTS8 chr11 130404923 130428609 - ADCY6 chr12 48766194 48789037 - AC020915.5 chr19 58228914 58315183 + ABLIM1 chr10 114431113 114768061 - ACTB chr7 5527148 5563784 - ABCF3 chr3 184186023 184194012 + AC004922.1 chr7 99325879 99394653 + AGBL5 chr2 27042364 27070622 + ALDH16A1 chr19 49453225 49471050 + AC007192.1 chr19 18153158 18178117 + AHSA1 chr14 77457870 77469472 + ACTG1 chr17 81509971 81523847 - ACADS chr12 120725774 120740008 + AC022384.1 chr3 10249372 10285796 + AL355916.3 chr14 61529128 61657964 + AC011455.2 chr19 38915404 38949855 - ACIN1 chr14 23058564 23095614 - AC245033.1 chr15 82536788 82573194 - AC091167.2 chr15 90249556 90272208 + ACSS2 chr20 34872146 34927962 + AL360181.3 chr10 133380017 133420271 + ACY1 chr3 51983340 51989197 + AC124312.1 chr15 24955034 25000276 + ACTR2 chr2 65227753 65271253 + ACLY chr17 41866917 41930542 - ALDH2 chr12 111766887 111817532 + ABCF1 chr6 30571393 30597179 + AC093323.1 chr4 6663396 6676755 + AHCY chr20 34280268 34311802 - AKAP1 chr17 57085092 57121346 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC007952.4 chr17 19112000 19112636 - AC009446.1 chr8 71675300 71702786 + AC023509.1 chr12 53441741 53467528 + AC026362.1 chr12 122975320 122982907 + AC068768.1 chr12 123262060 123262402 + AC079781.5 chr7 97851688 97972985 - AC092306.1 chr19 44803701 44804010 + AC106864.1 chr4 112693047 112706810 - AC245033.4 chr15 82533175 82540008 - AD000090.1 chr19 35557956 35581954 + AL136419.1 chr14 23969931 24051377 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.