exRNAdisease

Entry Detail

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General Information

Database ID: exR0371404 RNA Name: TPT1 RNA Type: mRNA Chromosome: chr13 Starnd: - Coordinate: Start Site(bp): 45333471 End Site(bp): 45341370 External Links: ENSG00000133112

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCB4 chr7 87401697 87480435 - AK2 chr1 33007940 33080996 - AKAP17A chrX 1591604 1602520 + AARSD1 chr17 42950526 42964498 - AGBL2 chr11 47659591 47715389 - AC092718.8 chr16 81022316 81096284 - AKAP1 chr17 57085092 57121346 + ADM chr11 10305073 10307397 + AL136454.1 chr1 192716132 192716653 + AAGAB chr15 67200667 67255195 - ACAP1 chr17 7336529 7351477 + AC105052.1 chr7 102582523 102642869 - AC112229.3 chr2 110402934 110473075 - AL121594.1 chr14 35122549 35317474 + ABR chr17 1003518 1229738 - AC005258.1 chr19 2269525 2341172 + AIFM2 chr10 70098223 70132934 - ADK chr10 74151202 74709963 + AL121753.1 chr20 35267885 35280043 - ACIN1 chr14 23058564 23095614 - AC073082.1 chr2 48632291 48755724 - AGO4 chr1 35808016 35857890 + AC073508.2 chr17 40627356 40665141 - AC120057.2 chr17 7240427 7244635 - AC010323.1 chr19 8308283 8321379 - ACBD3 chr1 226144679 226186741 - ADAR chr1 154582057 154628013 - ACTR1B chr2 97655939 97664044 - ACAD8 chr11 134253495 134265855 + ADD3 chr10 109996368 110135565 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3648 chr21 8987026 8987046 + hsa-miR-4426 chr1 192716333 192716349 + hsa-miR-4700-5p chr12 120723202 120723223 + hsa-miR-4700-3p chr12 120723233 120723258 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005062.1 chr7 19918981 20140453 - AC007952.4 chr17 19112000 19112636 - AC012321.1 chr16 69703065 69704652 + AC012531.2 chr12 54017110 54035361 + AC016876.2 chr17 7581964 7584086 - AC019155.2 chr7 125229579 125264291 - AC020663.1 chr16 4730115 4752565 - AC026362.1 chr12 122975320 122982907 + AC064802.1 chr8 114282067 114295839 + AC079781.5 chr7 97851688 97972985 - AC091564.7 chr11 6610883 6616594 - AC113414.1 chr5 162424042 163437326 - AC132217.1 chr11 2129121 2129964 - AC242426.2 chr1 147172755 147295734 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL096870.2 chr14 24209646 24215987 - AL121749.1 chr10 35604485 35608153 - AL136295.6 chr14 24198433 24199090 + AL137058.2 chr13 52600042 52642542 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.