exRNAdisease

Entry Detail

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General Information

Database ID: exR0371468 RNA Name: TRIM28 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 58544064 End Site(bp): 58550722 External Links: ENSG00000130726

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABHD14A-ACY1 chr3 51974706 51989183 + AC005258.1 chr19 2269525 2341172 + AC007192.1 chr19 18153158 18178117 + AC008982.1 chr19 38817471 38840178 - AC010422.3 chr19 12643831 12648397 - AC092647.5 chr7 55887277 55955239 + AC118553.2 chr1 99970011 100083321 + AC129492.3 chr17 8150816 8162975 - AC138811.2 chr16 18788063 18801519 - AC245033.1 chr15 82536788 82573194 - ACBD6 chr1 180269653 180502954 - ACLY chr17 41866917 41930542 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTR1A chr10 102461881 102502712 - ACTR3C chr7 150243916 150323725 - ACY1 chr3 51983340 51989197 + ADAM10 chr15 58588809 58749791 - ADAR chr1 154582057 154628013 - ADD1 chr4 2843857 2930076 + ADSL chr22 40346500 40390463 + AHCY chr20 34280268 34311802 - AHDC1 chr1 27534035 27604431 - AIDA chr1 222668013 222713210 - AK2 chr1 33007940 33080996 - AKAP12 chr6 151239967 151358559 + AKR1A1 chr1 45550543 45570049 + AL121758.1 chr20 646626 675800 - AL136295.5 chr14 24147548 24166452 + ALDOA chr16 30064164 30070457 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-6807-5p chr19 58550285 58550306 + hsa-miR-6807-3p chr19 58550354 58550376 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC060780.1 chr17 43148368 43171037 - AC069281.2 chr7 100572232 100578700 - AC109460.3 chr16 28974804 28990775 + AD000090.1 chr19 35557956 35581954 + AL022311.1 chr22 37876148 37895563 + AL117378.1 chr6 131901963 131920565 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.