exRNAdisease

Entry Detail

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General Information

Database ID: exR0371678 RNA Name: TUBA1C RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 49188736 End Site(bp): 49274603 External Links: ENSG00000167553

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADCK2 chr7 140672945 140696261 + AHCYL1 chr1 109984765 110023742 + ALDH7A1 chr5 126531200 126595362 - AC010323.1 chr19 8308283 8321379 - AL139011.2 chr1 160216800 160285130 - ADNP2 chr18 80109262 80147523 + ABR chr17 1003518 1229738 - ABCA2 chr9 137007234 137028922 - ACBD5 chr10 27195214 27242130 - AC027644.4 chr7 66628958 66811189 + AC093525.2 chr16 2496032 2520218 + ACAT2 chr6 159762045 159779112 + AK9 chr6 109492856 109691217 - ADORA1 chr1 203090654 203167405 + AHCY chr20 34280268 34311802 - ACTB chr7 5527148 5563784 - AGTRAP chr1 11736084 11754802 + ACIN1 chr14 23058564 23095614 - ACTR3 chr2 113890063 113962596 + AGBL3 chr7 134986508 135147963 + ACTG1 chr17 81509971 81523847 - AGK chr7 141551278 141655244 + ACTL6A chr3 179562886 179588407 + AC008982.1 chr19 38817471 38840178 - AL162231.3 chr9 34646645 34657113 + ALDOA chr16 30064164 30070457 + AL136454.1 chr1 192716132 192716653 + AC004922.1 chr7 99325879 99394653 + AC092143.1 chr16 89919165 89936092 + ACTR1B chr2 97655939 97664044 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-367-3p chr4 112647877 112647898 - hsa-miR-3610 chr8 116874740 116874759 - hsa-miR-3654 chr7 133034860 133034878 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC011298.1 chr2 240686334 240690414 + AC026362.1 chr12 122975320 122982907 + AC233266.2 chr2 91580336 91580863 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.