exRNAdisease

Entry Detail

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General Information

Database ID: exR0371752 RNA Name: UBA52 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 18571730 End Site(bp): 18577550 External Links: ENSG00000221983

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AATF chr17 36948954 37056871 + ABRACL chr6 139028745 139043302 + AC008763.3 chr19 7678501 7682854 + AC008982.1 chr19 38817471 38840178 - AC010422.3 chr19 12643831 12648397 - AC012254.2 chr18 47108188 47176345 - AC023055.1 chr12 55757275 55827546 - AC124312.1 chr15 24955034 25000276 + AC245033.1 chr15 82536788 82573194 - ACAT2 chr6 159762045 159779112 + ACLY chr17 41866917 41930542 - ACO1 chr9 32384603 32454769 + ACSF3 chr16 89088375 89164121 + ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACTR2 chr2 65227753 65271253 + AD000671.1 chr19 35745678 35754519 + ADAR chr1 154582057 154628013 - ADPGK chr15 72751369 72785846 - ADRM1 chr20 62302093 62308862 + AFF4 chr5 132875395 132963634 - AHCY chr20 34280268 34311802 - AIF1L chr9 131096476 131123152 + AIP chr11 67483026 67491103 + AL121594.1 chr14 35122549 35317474 + AL136295.5 chr14 24147548 24166452 + AL136454.1 chr1 192716132 192716653 + AL512428.1 chr6 24797373 24809798 - AL590764.2 chrX 71103987 71111575 - AL645941.2 chr6 32937364 32953122 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021078.1 chr5 149494314 149504670 - AC099329.1 chr3 42785087 42852428 - AC109460.3 chr16 28974804 28990775 + AC132217.1 chr11 2129121 2129964 - AD000090.1 chr19 35557956 35581954 + AL021368.4 chr6 57919912 57961382 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.