exRNAdisease

Entry Detail

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General Information

Database ID: exR0372957 RNA Name: AGAP11 RNA Type: lncRNA Chromosome: chr10 Starnd: + Coordinate: Start Site(bp): 86970741 End Site(bp): 87010126 External Links: ENSG00000271880

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AGAP1 chr2 235494043 236131800 + AGAP4 chr10 45825594 45853875 - AGAP5 chr10 73674285 73698159 - AGAP9 chr10 47501854 47523638 - ANKRD52 chr12 56237807 56258384 - ASXL1 chr20 32358330 32439319 + BMS1 chr10 42782795 42834937 + CHTF8 chr16 69118010 69132578 - FZD9 chr7 73433778 73436120 + HNRNPA1 chr12 54280193 54287088 + KPTN chr19 47475150 47484265 - PGPEP1 chr19 18340598 18369950 + PIGS chr17 28553383 28571794 - PRRC2A chr6 31620715 31637771 + RARS2 chr6 87513938 87589987 - RCOR1 chr14 102592649 102730561 + SEMA3C chr7 80742538 80922359 - TNPO2 chr19 12699194 12724011 - TPM2 chr9 35681992 35690056 - WDR73 chr15 84639281 84654343 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC022400.3 chr10 73674295 73730466 - AL136982.1 chr10 86992406 87010203 + AL512662.2 chr10 79904898 79951029 + SNHG11 chr20 38446343 38450940 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 945 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.