exRNAdisease

Entry Detail

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General Information

Database ID: exR0373004 RNA Name: DANCR RNA Type: lncRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 52712404 End Site(bp): 52720351 External Links: ENSG00000226950

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABCF1 chr6 30571393 30597179 + ABHD14A-ACY1 chr3 51974706 51989183 + AC009690.1 chr15 72284727 72375981 - ACOT7 chr1 6264269 6394391 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - ACVR1B chr12 51951699 51997078 + ACY1 chr3 51983340 51989197 + AKT2 chr19 40230317 40285536 - AL358113.1 chr9 69035747 69255187 + ALDOA chr16 30064164 30070457 + AC139530.2 chr17 81703371 81720539 + AKIP1 chr11 8911139 8920084 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-33a-5p chr22 41900949 41900969 + hsa-miR-216a-5p chr2 55989020 55989041 - hsa-miR-125b-5p chr21 16590253 16590274 + hsa-miR-135a-5p chr12 97563834 97563856 + hsa-miR-125a-5p chr19 51693268 51693291 + hsa-miR-135b-5p chr1 205448361 205448383 - hsa-miR-496 chr14 101060628 101060649 + hsa-miR-33b-5p chr17 17813897 17813916 - hsa-miR-656-3p chr14 101066766 101066786 + hsa-miR-758-3p chr14 101026071 101026092 + hsa-miR-214-5p chr1 172138857 172138878 - hsa-miR-874-3p chr5 137647582 137647603 - hsa-miR-1301-3p chr2 25328651 25328674 - hsa-miR-3180-3p chr16 16309936 16309957 + hsa-miR-3196 chr20 63238788 63238805 + hsa-miR-3200-3p chr22 30731610 30731631 + hsa-miR-4319 chr18 44970140 44970156 - hsa-miR-3180 chr16 15154949 15154967 - hsa-miR-4436a chr2 88812425 88812445 + hsa-miR-1343-3p chr11 34941888 34941909 + hsa-miR-5047 chr17 64501230 64501250 - hsa-miR-5000-3p chr2 75090873 75090894 + hsa-miR-506-5p chrX 147230788 147230809 - hsa-miR-1277-5p chrX 118386401 118386424 + hsa-miR-1306-5p chr22 20086072 20086093 + hsa-miR-6783-3p chr17 44934618 44934639 - hsa-miR-6816-5p chr22 20114726 20114746 - circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 945 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.