exRNAdisease

Entry Detail

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General Information

Database ID: exR0373068 RNA Name: HCG11 RNA Type: lncRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 26521709 End Site(bp): 26527404 External Links: ENSG00000228223

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-654-3p chr14 101040269 101040290 + hsa-miR-1297 chr13 54311981 54311997 - hsa-miR-576-5p chr4 109488713 109488734 + hsa-miR-129-2-3p chr11 43581450 43581471 + hsa-miR-656-3p chr14 101066766 101066786 + hsa-miR-579-3p chr5 32394392 32394414 - hsa-miR-522-3p chr19 53751264 53751285 + hsa-miR-539-3p chr14 101047369 101047390 + hsa-miR-144-3p chr17 28861548 28861567 - hsa-miR-485-3p chr14 101055464 101055485 + hsa-miR-26a-5p chr3 37969413 37969434 + hsa-miR-4424 chr1 178677763 178677784 + hsa-miR-1277-5p chrX 118386401 118386424 + hsa-miR-129-1-3p chr7 128207920 128207941 + hsa-miR-376c-3p chr14 101039732 101039752 + hsa-miR-3145-3p chr6 138435223 138435246 - hsa-miR-520h chr19 53742566 53742587 + hsa-miR-382-3p chr14 101054352 101054372 + hsa-miR-3163 chr11 66934476 66934497 - hsa-miR-483-3p chr11 2134142 2134162 - hsa-miR-499a-5p chr20 34990408 34990428 + hsa-miR-520g-3p chr19 53722220 53722243 + hsa-miR-4465 chr6 140683855 140683876 + hsa-miR-28-3p chr3 188688834 188688855 + hsa-miR-7853-5p chr6 6169380 6169400 - hsa-miR-4637 chr5 14825932 14825953 - hsa-miR-105-5p chrX 152394458 152394480 - hsa-miR-224-3p chrX 151958584 151958606 - hsa-miR-26b-5p chr2 218402657 218402677 + hsa-miR-545-5p chrX 74287164 74287185 - circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 945 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.