exRNAdisease

Entry Detail

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General Information

Database ID: exR0373162 RNA Name: LINC00641 RNA Type: lncRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 21200079 End Site(bp): 21206900 External Links: ENSG00000258441

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-1-3p chr18 21829015 21829036 - hsa-miR-206 chr6 52144401 52144422 + hsa-miR-320a-3p chr8 22244975 22244996 - hsa-miR-362-5p chrX 50008968 50008991 + hsa-miR-378a-3p chr5 149732867 149732888 + hsa-miR-323a-3p chr14 101025782 101025802 + hsa-miR-422a chr15 63870989 63871010 - hsa-miR-613 chr12 12764709 12764728 + hsa-miR-641 chr19 40282603 40282626 - hsa-miR-653-5p chr7 93482823 93482843 - hsa-miR-660-5p chrX 50013256 50013277 + hsa-miR-501-3p chrX 50009772 50009793 + hsa-miR-502-3p chrX 50014649 50014670 + hsa-miR-320b chr1 224257049 224257070 - hsa-miR-320c chr18 24321716 24321735 + hsa-miR-320d chr13 40727828 40727846 - hsa-miR-378b chr3 10330262 10330280 + hsa-miR-500b-5p chrX 50010682 50010699 + hsa-miR-3617-5p chr20 45705150 45705171 - hsa-miR-378d chr4 5923279 5923298 - hsa-miR-378e chr5 170028545 170028563 + hsa-miR-378f chr1 23929121 23929140 + hsa-miR-4429 chr2 11540652 11540671 - hsa-miR-378h chr5 154829466 154829486 + hsa-miR-378i chr22 41923271 41923291 - hsa-miR-212-5p chr17 2050328 2050350 - hsa-miR-873-3p chr9 28888889 28888910 - circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 945 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.