exRNAdisease

Entry Detail

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General Information

Database ID: exR0373307 RNA Name: SNHG16 RNA Type: lncRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 76557764 End Site(bp): 76565348 External Links: ENSG00000163597

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC015802.6 chr17 76563710 76570544 - AC015813.2 chr17 57989038 58007246 - AC245033.1 chr15 82536788 82573194 - ACTG1 chr17 81509971 81523847 - AGPAT1 chr6 32168212 32178096 - AL022238.4 chr22 40346529 40410054 + AC138969.1 chr16 16317444 16350590 + ACP5 chr19 11574660 11579008 - ADAMTS15 chr11 130448974 130476641 + AIMP1 chr4 106315544 106349456 + ALDH3A2 chr17 19648136 19685760 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-195-5p chr17 7017667 7017687 - hsa-miR-15b-5p chr3 160404607 160404628 + hsa-miR-421 chrX 74218392 74218414 - hsa-miR-302d-3p chr4 112648006 112648028 - hsa-miR-216a-3p chr2 55988981 55989002 - hsa-miR-4458 chr5 8460933 8460951 + hsa-miR-500b-5p chrX 50010682 50010699 + hsa-miR-4500 chr13 87618671 87618687 - hsa-miR-372-3p chr19 53787931 53787953 + hsa-miR-508-3p chrX 147236945 147236967 - hsa-miR-510-5p chrX 147272378 147272399 - hsa-miR-3619-5p chr22 46091059 46091080 + hsa-miR-2467-3p chr2 239351732 239351753 - hsa-miR-2681-3p chr13 101967665 101967686 - hsa-miR-664b-3p chrX 154768635 154768656 + hsa-miR-761 chr1 51836375 51836396 - hsa-miR-30b-5p chr8 134800570 134800591 - hsa-miR-5047 chr17 64501230 64501250 - hsa-miR-6823-3p chr3 48549961 48549981 - hsa-miR-196b-5p chr7 27169528 27169549 - hsa-let-7i-5p chr12 62603691 62603712 + hsa-miR-193a-5p chr17 31560016 31560037 + hsa-miR-30d-5p chr8 134804919 134804940 - hsa-miR-20a-5p chr13 91351072 91351094 + hsa-miR-141-3p chr12 6964155 6964176 + hsa-miR-212-3p chr17 2050290 2050310 - hsa-let-7c-5p chr21 16539838 16539859 + hsa-miR-1301-3p chr2 25328651 25328674 - hsa-miR-424-5p chrX 134546680 134546701 - hsa-miR-485-5p chr14 101055427 101055448 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC007996.1 chr18 26542971 26545791 - AC093827.4 chr4 86924630 86936202 - AC138904.1 chr16 28284885 28292064 - AC245014.3 chr1 145281116 145281462 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 945 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.