exRNAdisease

Entry Detail

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General Information

Database ID: exR0373311 RNA Name: SNHG5 RNA Type: lncRNA Chromosome: chr6 Starnd: - Coordinate: Start Site(bp): 85650491 End Site(bp): 85678932 External Links: ENSG00000203875

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACTB chr7 5527148 5563784 - AK1 chr9 127866486 127877675 - AK2 chr1 33007940 33080996 - ALDOA chr16 30064164 30070457 + AD000671.2 chr19 35739252 35745432 - AHSA1 chr14 77457870 77469472 + AKIRIN1 chr1 38991276 39006059 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-552-5p chr1 34669650 34669670 - hsa-miR-32-5p chr9 109046272 109046293 - hsa-miR-181a-5p chr1 198859108 198859130 - hsa-miR-369-3p chr14 101065641 101065661 + hsa-miR-130a-5p chr11 57641212 57641233 + hsa-miR-216a-5p chr2 55989020 55989041 - hsa-miR-25-3p chr7 100093571 100093592 - hsa-miR-5590-3p chr2 134857853 134857873 + hsa-miR-1197 chr14 101025620 101025640 + hsa-miR-4465 chr6 140683855 140683876 + hsa-miR-655-3p chr14 101049610 101049631 + hsa-miR-2355-3p chr2 207109999 207110020 - hsa-miR-323a-3p chr14 101025782 101025802 + hsa-miR-142-5p chr17 58331283 58331303 - hsa-miR-421 chrX 74218392 74218414 - hsa-miR-181d-5p chr19 13874910 13874932 + hsa-miR-132-3p chr17 2049929 2049950 - hsa-miR-92b-3p chr1 155195237 155195258 + hsa-miR-26b-5p chr2 218402657 218402677 + hsa-miR-363-3p chrX 134169382 134169403 - hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-23c chrX 20017101 20017122 - hsa-miR-23a-3p chr19 13836595 13836615 - hsa-miR-26a-5p chr3 37969413 37969434 + hsa-miR-6509-3p chr7 135207006 135207027 - hsa-miR-1297 chr13 54311981 54311997 - hsa-miR-377-3p chr14 101062094 101062115 + hsa-miR-23b-3p chr9 95085265 95085287 + hsa-miR-374c-5p chrX 74218561 74218582 + hsa-miR-4262 chr2 11836943 11836959 - circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 945 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.