Entry Detail



General Information

Database ID:exR0373313
RNA Name:SNHG7
RNA Type:lncRNA
Chromosome:chr9
Starnd:-
Coordinate:
Start Site(bp):136721366End Site(bp):136728184
External Links:ENSG00000233016



Disease Information

Disease Name:Amyotrophic Lateral Sclerosis
Disease Category:Nervous System Diseases
MeSH ID:D000690
Type:Diseases Category/Nervous System Diseases
Alias:Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis



Expression Detail

GEO ID:GSE121519
Description:Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid.
Experimental Design:Disease vs Control
Case Disease Type:Amyotrophic Lateral Sclerosis
Case Disease SubType:NA
Case Sample:Amyotrophic Lateral Sclerosis
Control Sample:Healthy
Number of Case:4
Number of Control:4
Number of Samples:8





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005670.2
chr17
46923133
47049932
+
AC245033.1
chr15
82536788
82573194
-
ACO2
chr22
41469117
41528989
+
AD000671.1
chr19
35745678
35754519
+
ADARB1
chr21
45073853
45226560
+
miRNA targets:
miRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa-miR-34a-5p
chr1
9151735
9151756
-
hsa-miR-181a-5p
chr1
198859108
198859130
-
hsa-miR-181b-5p
chr9
124693725
124693747
+
hsa-miR-181c-5p
chr19
13874725
13874746
+
hsa-miR-122-5p
chr18
58451088
58451109
+
hsa-miR-9-5p
chr5
88666902
88666924
-
hsa-miR-186-5p
chr1
71067681
71067702
-
hsa-miR-34b-5p
chr11
111512950
111512972
+
hsa-miR-34c-5p
chr11
111513451
111513473
+
hsa-miR-342-3p
chr14
100109715
100109737
+
hsa-miR-331-3p
chr12
95308480
95308500
+
hsa-miR-449a
chr5
55170586
55170607
-
hsa-miR-181d-5p
chr19
13874910
13874932
+
hsa-miR-625-5p
chr14
65471116
65471136
+
hsa-miR-449b-5p
chr5
55170706
55170727
-
hsa-miR-653-5p
chr7
93482823
93482843
-
hsa-miR-425-5p
chr3
49020199
49020221
-
hsa-miR-214-5p
chr1
172138857
172138878
-
hsa-miR-574-5p
chr4
38868056
38868078
+
hsa-miR-543
chr14
101032033
101032054
+
hsa-miR-216b-5p
chr2
56000764
56000785
-
hsa-miR-941
chr20
63919551
63919573
+
hsa-miR-449c-5p
chr5
55172313
55172337
-
hsa-miR-2682-5p
chr1
98045307
98045329
-
hsa-miR-3186-3p
chr17
81451116
81451136
-
hsa-miR-4262
chr2
11836943
11836959
-
hsa-miR-4436a
chr2
88812425
88812445
+
hsa-miR-5000-3p
chr2
75090873
75090894
+
hsa-miR-506-5p
chrX
147230788
147230809
-
hsa-miR-579-5p
chr5
32394430
32394451
-
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC020663.1
chr16
4730115
4752565
-
AC020978.7
chr16
68224713
68227734
+
AC074183.1
chr7
84939349
84940245
-
AC245033.4
chr15
82533175
82540008
-
Display:



Experiment Detail

GEO ID:GSE121519
Sample Source:Cerebrospinal Fluid
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:2
Num of detected RNAs of this Type:945
Sample treatment protocol:Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant.
RNA Extract protocol:Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted.
RNA library preparation protocol:Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.



Reference

PMID:30630471
Title:Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid
Author:Otake K, Kamiguchi H, Hirozane Y
Journal:BMC Med Genomics. 2019 Jan 10;12(1):7.
Description:The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.