exRNAdisease

Entry Detail

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General Information

Database ID: exR0373314 RNA Name: SNHG8 RNA Type: lncRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 118278709 End Site(bp): 118285316 External Links: ENSG00000269893

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC048338.1 chr12 122207779 122266423 - ACTB chr7 5527148 5563784 - ACTG1 chr17 81509971 81523847 - AFG1L chr6 108294991 108526796 + ALDOA chr16 30064164 30070457 + AC024592.3 chr19 5866171 5903787 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-149-5p chr2 240456015 240456037 + hsa-miR-154-5p chr14 101059769 101059790 + hsa-miR-384 chrX 76919285 76919304 - hsa-miR-494-3p chr14 101029681 101029702 + hsa-miR-522-3p chr19 53751264 53751285 + hsa-miR-588 chr6 126484646 126484666 + hsa-miR-620 chr12 116148575 116148594 - hsa-miR-411-5p chr14 101023340 101023360 + hsa-miR-656-3p chr14 101066766 101066786 + hsa-miR-542-3p chrX 134541364 134541385 - hsa-miR-425-5p chr3 49020199 49020221 - hsa-miR-371a-5p chr19 53787680 53787699 + hsa-miR-1270 chr19 20399320 20399342 - hsa-miR-224-3p chrX 151958584 151958606 - hsa-miR-4701-5p chr12 48772014 48772035 - hsa-miR-506-5p chrX 147230788 147230809 - hsa-miR-873-3p chr9 28888889 28888910 - hsa-miR-7151-5p chr10 67403388 67403410 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC068205.2 chr11 43578889 43840030 + AC139149.1 chr17 81514047 81527776 + AL133215.2 chr10 101060029 101061005 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 945 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.