Entry Detail


General Information

Database ID:exR0409382
RNA Name:hsa-miR-106b-5p
RNA Type:miRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):100094043End Site(bp):100094063
External Links:hsa-miR-106b-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MTHFR
chr1
11785723
11806455
-
MYCN
chr2
15940550
15947007
+
PXDN
chr2
1631887
1744852
-
C9orf40
chr9
74946583
74952912
-
PPARD
chr6
35342558
35428191
+
AFF4
chr5
132875395
132963634
-
WDR37
chr10
1049538
1132384
+
RAB31
chr18
9708275
9862551
+
SCAMP2
chr15
74843730
74873365
-
OCRL
chrX
129539849
129592561
+
ZSCAN26
chr6
28267010
28278224
+
ZNF566
chr19
36445119
36489902
-
APP
chr21
25880550
26171128
-
AMPD2
chr1
109616104
109632053
+
FOXK1
chr7
4682295
4771442
+
ZDHHC12
chr9
128720870
128724127
-
KLHL28
chr14
44924319
45042322
-
ZNF468
chr19
52838010
52857649
-
RACGAP1
chr12
49976923
50033136
-
STRN3
chr14
30893799
31026401
-
USP24
chr1
55066359
55215364
-
WDR36
chr5
111091716
111130502
+
LONP2
chr16
48244300
48363122
+
LDLRAD3
chr11
35943981
36232136
+
PBXIP1
chr1
154944076
154956123
-
WASF3
chr13
26557683
26688948
+
RPP14
chr3
58306247
58324695
+
SLAIN2
chr4
48341529
48426201
+
PXYLP1
chr3
141228726
141367753
+
MTERF4
chr2
241072169
241102332
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000494
chr13
76134888
76143643
+
hsa_circ_0000018
chr1
15860731
15863309
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC015871.3
chr15
79920195
79922455
-
AC021078.1
chr5
149494314
149504670
-
AC021092.1
chr19
44103007
44113183
-
AC024940.6
chr12
31280422
31280895
-
AC084082.1
chr8
66112667
66126632
+
AC087477.2
chr15
96354237
96405235
+
AC243964.3
chr19
44631573
44725217
-
AL031428.1
chr1
23020147
23088058
-
AL137782.1
chr13
75549773
75807120
+
AL158206.1
chr9
19453209
19455173
+
AL161772.1
chr13
20699307
20703718
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
CKMT2-AS1
chr5
81201341
81301565
-
EPB41L4A-AS1
chr5
112160526
112164818
+
ERICD
chr8
140636281
140638283
+
FGD5-AS1
chr3
14920347
14948424
-
H19
chr11
1995176
2001470
-
HAGLR
chr2
176164051
176188958
-
HOTAIR
chr12
53962308
53974956
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.