Entry Detail


General Information

Database ID:exR0409415
RNA Name:hsa-miR-1286
RNA Type:miRNA
Chromosome:chr22
Starnd:-
Coordinate:
Start Site(bp):20249145End Site(bp):20249165
External Links:hsa-miR-1286



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TRIO
chr5
14143342
14532128
+
TXLNA
chr1
32179675
32198285
+
CSNK1E
chr22
38290691
38318084
-
NT5DC2
chr3
52524385
52535054
-
ERLIN1
chr10
100150094
100186033
-
BTG2
chr1
203305491
203309602
+
GOLGA3
chr12
132768914
132829078
-
ABCA2
chr9
137007234
137028922
-
SSR2
chr1
156009048
156020951
-
LUZP1
chr1
23084023
23177808
-
RUBCN
chr3
197668867
197749727
-
CBX6
chr22
38861422
38872249
-
KMT2A
chr11
118436490
118526832
+
LAMTOR1
chr11
72085895
72103297
-
PHF12
chr17
28905250
28951771
-
NPTX1
chr17
80466834
80477843
-
ZXDB
chrX
57591652
57597545
+
PHLDA3
chr1
201464278
201469237
-
NIPSNAP1
chr22
29554808
29581327
-
IGDCC3
chr15
65327127
65378002
-
TNRC6B
chr22
40044817
40335808
+
DNAJC30
chr7
73680918
73683453
-
ALG10B
chr12
38316762
38329721
+
RBM4
chr11
66638617
66668374
+
ABHD14B
chr3
51968510
51983409
-
ATXN2L
chr16
28823035
28837237
+
CPA4
chr7
130293134
130324180
+
FGFR1
chr8
38400215
38468834
-
HDGF
chr1
156742109
156766925
-
ATP8B2
chr1
154325553
154351304
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001588
chr6
26204839
26205043
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010327.5
chr19
55216660
55221616
+
AC016876.2
chr17
7581964
7584086
-
AC124068.2
chr15
89335053
89336161
+
DNAAF4-CCPG1
chr15
55355248
55498360
-
MIR497HG
chr17
7015818
7019659
-
NEAT1
chr11
65422774
65445540
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.