Entry Detail


General Information

Database ID:exR0409436
RNA Name:hsa-miR-138-5p
RNA Type:miRNA
Chromosome:chr16
Starnd:+
Coordinate:
Start Site(bp):56858527End Site(bp):56858549
External Links:hsa-miR-138-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
KRT80
chr12
52168996
52192014
-
STX3
chr11
59713456
59805882
+
SIN3A
chr15
75369379
75455842
-
RNH1
chr11
494512
507300
-
ACTN4
chr19
38647649
38731589
+
CDCA7L
chr7
21900899
21945903
-
COPS7B
chr2
231781671
231809254
+
LARP4B
chr10
806914
931705
-
GSK3A
chr19
42230190
42242625
-
GNAI2
chr3
50226292
50259362
+
NINJ1
chr9
93121496
93134251
-
IGF2BP1
chr17
48997385
49056145
+
TFAP2A
chr6
10393186
10419659
-
FOXC1
chr6
1609915
1613897
+
PATL1
chr11
59636716
59669037
-
SRF
chr6
43171269
43181506
+
MAFG
chr17
81918270
81927735
-
AHDC1
chr1
27534035
27604431
-
FOXP4
chr6
41546426
41602384
+
HIF1AN
chr10
100529072
100559998
+
PRKACA
chr19
14091688
14118084
-
SMG1
chr16
18804853
18926454
-
IQGAP1
chr15
90388242
90502239
+
CTDSP1
chr2
218398256
218405941
+
HMGA1
chr6
34236873
34246231
+
KLF11
chr2
10042849
10054836
+
ZHX2
chr8
122781655
122974510
+
IQSEC1
chr3
12897043
13283281
-
PLXNB2
chr22
50274979
50307646
-
TRIB1
chr8
125430358
125438403
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0000402
chr12
53670403
53671011
+
hsa_circ_0000798
chr17
65941524
65944422
+
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC092718.4
chr16
81030770
81031485
+
AC144548.1
chr12
110387463
110445548
-
AL137127.1
chr1
19072110
19075511
-
H19
chr11
1995176
2001470
-
MCF2L-AS1
chr13
112967484
112968824
-
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
PARD6G-AS1
chr18
80147924
80179839
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
TUG1
chr22
30969245
30979395
+
TFAP2A-AS1
chr6
10409340
10416446
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.