Entry Detail


General Information

Database ID:exR0409437
RNA Name:hsa-miR-140-3p
RNA Type:miRNA
Chromosome:chr16
Starnd:+
Coordinate:
Start Site(bp):69933142End Site(bp):69933162
External Links:hsa-miR-140-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ARF3
chr12
48935723
48957487
-
ARL1
chr12
101393116
101407772
-
ATP6V0D1
chr16
67438014
67481181
-
CBL
chr11
119206298
119313926
+
CDK6
chr7
92604921
92836594
-
CLASP1
chr2
121337776
121649587
-
CORO1C
chr12
108645109
108731596
-
CRCP
chr7
66114604
66154568
+
CRY2
chr11
45847118
45883248
+
NDST1
chr5
150485818
150558211
+
RNF220
chr1
44405194
44651724
+
SLC31A1
chr9
113221544
113264492
+
TMEM50A
chr1
25338317
25362361
+
ZDHHC6
chr10
112424428
112446917
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001880
chr9
110084263
110087285
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0000032
chr1
25666964
25669564
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC245014.3
chr1
145281116
145281462
+
AL049840.4
chr14
103694516
103695050
-
AL356488.2
chr1
109100193
109100619
+
KCNQ1OT1
chr11
2608328
2699994
-
MIR17HG
chr13
91347820
91354579
+
MIR29B2CHG
chr1
207801518
207879115
-
MIR497HG
chr17
7015818
7019659
-
MIR663AHG
chr20
26167817
26251546
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.