Entry Detail


General Information

Database ID:exR0409442
RNA Name:hsa-miR-144-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):28861548End Site(bp):28861567
External Links:hsa-miR-144-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANXA2
chr15
60347134
60402883
-
ARHGAP18
chr6
129576132
129710177
-
CNOT11
chr2
101252886
101270316
+
EPHA7
chr6
93240020
93419559
-
G3BP2
chr4
75642782
75724525
-
GABPB1
chr15
50275392
50355408
-
IKZF2
chr2
212999691
213152427
-
RAB15
chr14
64945814
64973226
-
ROCK2
chr2
11179759
11348330
-
SGPP1
chr14
63684216
63728065
-
USP47
chr11
11841423
11961887
+
ZNF695
chr1
246945547
247008093
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001376
chr3
194169185
194175121
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010980.2
chr2
222317242
222318653
-
AC022167.2
chr16
8848105
8860456
+
AC093010.3
chr3
114314501
114329714
-
AF254983.1
chr21
10482738
10605716
+
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
EBLN3P
chr9
37079645
37090928
+
HCG11
chr6
26521709
26527404
+
LINC00662
chr19
27681072
27794005
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OTUD6B-AS1
chr8
91059318
91070583
-
SDCBP2-AS1
chr20
1325405
1378735
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.