Entry Detail


General Information

Database ID:exR0409456
RNA Name:hsa-miR-151a-3p
RNA Type:miRNA
Chromosome:chr8
Starnd:-
Coordinate:
Start Site(bp):140732587End Site(bp):140732607
External Links:hsa-miR-151a-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACP1
chr2
264140
278283
+
PCDHA1
chr5
140786136
141012347
+
PCDHA10
chr5
140855883
141012347
+
PCDHA11
chr5
140868183
141012344
+
PCDHA12
chr5
140875302
141012347
+
PCDHA13
chr5
140882124
141012347
+
PCDHA2
chr5
140794852
141012347
+
PCDHA3
chr5
140801028
141012347
+
PCDHA4
chr5
140806929
141012347
+
PCDHA5
chr5
140821604
141012347
+
PCDHA6
chr5
140827958
141012347
+
PCDHA7
chr5
140834248
141012347
+
PCDHA8
chr5
140841187
141012347
+
PCDHA9
chr5
140847463
141012344
+
PCDHAC1
chr5
140926369
141012344
+
PCDHAC2
chr5
140966470
141012347
+
STRBP
chr9
123109500
123268586
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC044784.1
chr10
8970125
8973468
+
AC104794.2
chr2
10083781
10086101
+
AL160006.1
chr1
110058340
110062555
+
SCARNA9
chr11
93721513
93721865
+
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.